Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer
What is non-small cell lung cancer?
About 85% to 90% of lung cancers are non-small cell lung cancer (NSCLC). There are 3 main subtypes of NSCLC. The cells in these subtypes differ in size, shape, and chemical make-up when looked at under a microscope. But they are grouped together because the approach to treatment and prognosis (outlook) are very similar.
- Squamous (epidermoid) cell cancer
- Adenocarcinoma:
- Large cell (undifferentiated) carcinoma
- Other subtypes
What is non-small cell lung cancer?
Non-small cell is the most common type of lung cancer. It happens when abnormal cells grow out of control in the lungs. The cells form tumors and invade nearby tissue. It usually starts in the breathing (bronchial) tubes in the lungs.
Appointment Information
The Lung Cancer Program evaluates and treats patients with known or suspected lung tumors and severe emphysema. Each week, a team of thoracic surgeons, medical oncologists, pathologists, radiation oncologists and other experts reviews each patient's case and provides a personalized treatment plan.
If you've been diagnosed with lung cancer, or suspect you may have it, please call 734-647-8902.
If you're referring a patient, please contact M-Line 800-962-3555.
For people with questions, please call our Cancer AnswerLine at 800-865-1125.
Types of non-small cell lung cancer
There are 3 main subtypes of NSCLC. The cells in these subtypes differ in size, shape, and chemical make-up when looked at under a microscope. But they are grouped together because the approach to treatment and prognosis (outlook) are very similar.
Squamous (epidermoid) cell cancer:
About 25% to 30% of all lung cancers are squamous cell carcinomas. These cancers start in early versions of squamous cells, which are flat cells that line the inside of the airways in the lungs. They are often linked to a history of smoking and tend to be found in the middle of the lungs, near a bronchus.
Adenocarcinoma:
About 40% of lung cancers are adenocarcinomas. These cancers start in early versions of the cells that would normally secrete substances such as mucus. This type of lung cancer occurs mainly in people who smoke (or have smoked), but it is also the most common type of lung cancer seen in non-smokers. It is more common in women than in men, and it is more likely to occur in younger people than other types of lung cancer.
Large cell (undifferentiated) carcinoma:
This type of cancer accounts for about 10% to 15% of lung cancers. It may appear in any part of the lung. It tends to grow and spread quickly, which can make it harder to treat.
Other subtypes
This type of cancer accounts for about 10% to 15% of lung cancers. It may appear in any part of the lung. It tends to grow and spread quickly, which can make it harder to treat.
What are the symptoms of non-small cell lung cancer?
The symptoms of early non-small cell lung cancer may include a cough that does not go away, chest pain, wheezing, shortness of breath, and fatigue. The symptoms of later stages can include swelling of the face and coughing up blood. They can also include bone pain, hoarseness, trouble swallowing, and weight loss.
How is non-small cell lung cancer diagnosed?
A biopsy and chest X-rays are used to diagnose non-small cell lung cancer. You may have a CT scan and other tests. Your doctor will also do a physical exam. The doctor will ask about your symptoms, your past health, if you smoke or have smoked, and any family history of cancer.
How is non-small cell lung cancer treated?
Treatment for non-small cell lung cancer is based on the stage of the cancer and other things, such as your overall health. The main treatments are:
- Surgery. Surgery may be an option if your doctor thinks all of the cancer can be removed. The doctor may remove just the tumor, the affected part of the lung, or one whole lung.
- Radiation therapy. This uses high-dose X-rays to kill cancer cells and shrink tumors. It may be used with surgery or instead of surgery.
- Chemotherapy.These medicines kill fast-growing cells, including cancer cells and some normal cells. Chemotherapy and radiation may be given together. (This is called chemoradiation.)
A very small tumor may be destroyed using highly focused light, heat, or cold.
Other options may include immunotherapy or targeted therapy. Sometimes a clinical trial may be a good choice.
Your doctor will talk with you about your options and then make a treatment plan.
Questions about cancer?
Contact our Cancer AnswerLine™ at 800-865-1125. You'll talk to a nurse with years of experience in cancer care.
Locations
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Thoracic Oncology Clinic | Rogel Cancer Center 1500 E Medical Center Dr
Floor B1 Reception E
Ann Arbor, MI 48109-5912Get Directions -
Thoracic Surgery Clinic | Taubman Center 1500 E Medical Center Dr
Floor 2 Reception C
Ann Arbor, MI 48109-5344Get Directions
Doctors
Andrew Ching-Hung Chang, MD
Professor
Thoracic Surgery, Surgery
Aleksandar Filip Dragovic, MD
Clinical Associate Professor
Radiation Oncology
Peggy Ping Hsu, MD, PhD
Clinical Instructor
Medical Oncology, Internal Medicine
Shruti Jolly, MD, MBA
Clinical Professor
Radiation Oncology
Gregory Peter Kalemkerian, MD
Clinical Professor
Medical Oncology, Internal Medicine
Kiran Hari Lagisetty, MD
Clinical Associate Professor
Thoracic Surgery, Surgery
Jules Lin, MD
Professor
Thoracic Surgery, Surgical Critical Care, Surgery
William Robert Lynch, MD
Clinical Associate Professor
Thoracic Surgery, Surgical Critical Care, Surgery
Arathi Mohan, MD
Clinical Assistant Professor
Medical Oncology, Internal Medicine
David Duston Odell, MD
Professor
Thoracic Surgery, Surgery