Pre-implantation Genetic Diagnosis

Pre-implantation Genetic Diagnosis

  • Overview
  • Approach
  • Appointments
  • Locations
  • Doctors
  • Providers

    • What is pre-implantation genetic diagnosis?

    At the University of Michigan Health Center for Reproductive Medicine, we offer a cutting-edge procedure called pre-implantation genetic diagnosis to identify genetic disorders in embryos, and then implant the unaffected embryos using in vitro fertilization. Because of our strong medical genetics program, our center is well situated to offer Pre-implantation genetic diagnosis services to our patients in a timely and efficient manner.

    How are inherited genetic disorders diagnosed?

    Pre-implantation genetic diagnosis is performed when one or both genetic parents have a known genetic abnormality. Testing is performed on an embryo to determine if it also carries the genetic abnormality. This allows us to detect genetic diseases before pregnancy.

    What are the types of inherited genetic disorders?

    This procedure is used to look for DNA-testable disorders with significant morbidities in which quality of life is dramatically affected, including:

    Our Approach

    To determine if you and your partner are candidates for the procedure, you will meet with our genetic counselor to discuss both your case and your options. All the testing performed for in vitro fertilization, including blood tests and ultrasound will be scheduled. You will also require hormone treatment to control your egg production.

    During the process, embryos are created using in vitro fertilization, where eggs and sperm are brought together in a laboratory glass dish to allow the sperm to fertilize an egg. On the third day — when the embryos reach the six- to eight-cell stage — a biopsy is performed to remove one or two cells and determine whether they carry the genetic abnormality. Embryos that are found to not carry the genetic defect are then transferred to the womb. Just over a week later, a pregnancy test will be conducted.

    Pregnancy is not guaranteed and depends on a variety of factors including your age and the number/quality of your embryos.

    Appointment Information

    Schedule an appointment by calling us at 734-763-6295.

    Locations
    • Reproductive Endocrinology Clinic | Center for Reproductive Medicine 475 Market Place
      Briarwood Building 1
      Ann Arbor, MI 48108-1649       Get Directions

    Doctors

     Search for a U-M Health doctor     Hanh Nguyen Cottrell, MD

    Hanh Nguyen Cottrell, MD

    Clinical Assistant Professor

    Reproductive Endocrinology, Obstetrics & Gynecology

    James Michael Dupree, IV, MD

    James Michael Dupree, MD

    Clinical Professor

    Urology

    Erica Elizabeth Marsh, MD

    Erica Elizabeth Marsh, MD, MSCI, FACOG

    Professor

    Reproductive Endocrinology, Obstetrics & Gynecology

    Marie Menke, MD

    Marie Menke, MD

    Clinical Associate Professor

    Obstetrics & Gynecology, Reproductive Endocrinology

    Dana Alan Ohl, MD

    Dana Alan Ohl, MD

    Professor

    Urology

    John F Randolph, MD

    Professor

    Reproductive Endocrinology, Obstetrics & Gynecology

    Samantha Beth Schon, MD

    Samantha Beth Schon, MD

    Associate Professor

    Reproductive Endocrinology, Obstetrics & Gynecology

    Yolanda Smith, MD

    Professor

    Reproductive Endocrinology, Obstetrics & Gynecology

    Natalie Clark Stentz, MD

    Natalie Clark Stentz, MD

    Clinical Assistant Professor

    Reproductive Endocrinology, Obstetrics & Gynecology

    Daphna Stroumsa, MD

    Daphna Stroumsa, MD, MPH

    Assistant Professor

    Obstetrics & Gynecology

    Providers

     Search for a U-M Health provider     Lindsay Renee Brennan, MSW

    Lindsay Renee Brennan, MSW

    Social Worker

    Licensed Clinical Social Worker

    News & Stories
    Computer screens and microscope pictured in a laboratory setting.
    Health Lab

    Understanding family history key to early detection of pancreatic cancer

    How genetic testing and family history help identify individuals at high risk for pancreatic cancer, enabling earlier screening and better treatment outcomes.
         Michael Powers pictured here holding a fish he caught as he stands in a boat. He struggled with pancreatitis for several decades and found answers at University of Michigan Health.
    Health Lab

    Patient with rare form of diabetes finds answers in genetic testing, clinical trials

    Discover how genetic testing and a groundbreaking clinical trial helped one man overcome rare hyperchylomicronemia, high triglycerides, and pancreatitis.
         Woman's torso in a blue hospital gown, with her hands holding a pregnant belly and an IV in place.
    Health Lab

    High dose oxytocin protocol linked to lower postpartum hemorrhage rates

    A change in how oxytocin is administered after childbirth may help reduce postpartum hemorrhage, a new study suggests.
         Three people stand arm in arm with backs to camera studying a wall of family mementos
    Health Lab

    Online resources and coaching helped people seek genetic testing for cancer

    New study from researchers at the University of Michigan Rogel Cancer Center showed an online resource and phone-based coaching both helped increase rates of genetic testing.
         Gene editing, conceptual illustration. DNA (deoxyribonucleic acid) double helix under a magnifying glass
    Health Lab

    Gene editing is coming for common diseases. Are we ready?

    Gene therapies may offer one-time treatment for disease, but experts say safety, reversibility, cost and long-term monitoring must guide use.
         female surgeon on ground upset hands to face in scrubs and scrub shoes
    Health Lab

    Depression in OBGYN residents needs more attention, study suggests

    New onset depression in obstetrics and gynecology residents in their intern year is common and often untreated, and linked to depression history, higher work hours and less sleep.