Antiphospholipid Syndrome Program
Antiphospholipid Syndrome Program
The Antiphospholipid Syndrome (APS) Program at U-M Health is home to both clinical and research activities associated with APS. That means that while team members are focused on providing the highest level of care for each patient, they are also dedicated to research to find new and better ways to treat and ultimately cure APS.
Our Approach
Our approach to treatment recognizes that APS is different in every person. We provide specialists in hematology, obstetrics, neurology, nephrology and more. Additionally, our rheumatologists work with each patient to develop a personalized treatment approach to pursue the very best possible long-term outcome.
Appointment Information
A doctor’s referral is recommended for new patients. Physicians can connect with the clinic by calling MLine, our 24/7 physician-to-physician portal, at 1-800-962-3555.
We recommend that new patients who are referred by doctors outside of U-M Health bring copies of all laboratory and imaging tests to their first appointment. Access to the latest information allows us to develop a treatment plan as quickly as possible. Existing patients who have questions about treatment or about scheduling or rescheduling appointments can phone the clinic directly at 1-888-229-3065.
APS Program Community Q&A Series
The APS Program Community Q&A Series, written by Yu (Ray) Zuo, MD, addresses questions received from the APS Program community and will cover a variety of topics.
Research
Ongoing research at U-M Health seeks to understand why certain people develop Antiphospholipid syndrome (APS), to find new and better ways to treat the disease, and ultimately, to find a cure. Collaborations with researchers in Biomedical Engineering, Cardiovascular Medicine and Vascular Surgery are taking on APS from all angles, using the latest advances in cell and molecular biology, pharmacology, genetics and epigenetics.
Projects include:
- Pursuing anti-inflammatory treatments that might provide a more targeted approach with fewer side effects. Specifically, investigators are exploring the role that neutrophils - the most abundant white blood cells in the body - play in APS.
- The program collaborates with many national and international partners, providing our patients access to the latest clinical trials and study protocols.
Patients who wish to are given the opportunity to participate in research at every clinic visit, by donating blood for studies into the genetic and cellular causes of APS.
These studies would not be possible without samples of blood from people who have antiphospholipid antibodies. By partnering with us in research, patients have a chance to make a positive impact on their own care and the care of future patients around the world.
- To learn more about our research, please visit our APS research lab website.
To receive updates on our patient care and research efforts, please join our APS Program email list.
Locations
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Rheumatology Clinic | Brighton Center for Specialty Care 7500 Challis Rd
Entrance 1, Level 1
Brighton, MI 48116-9416Get Directions -
Rheumatology Clinic | Taubman Center 1500 E Medical Center Dr
Floor 3 Reception A
Ann Arbor, MI 48109-5358Get Directions
Doctors
Jason Scott Knight, MD
Professor
Rheumatology, Internal Medicine
Jacqueline Anne Madison, MD
Clinical Assistant Professor
Rheumatology, Pediatric Rheumatology, Internal Medicine, Pediatrics
Ajay Tambralli, MD
Clinical Assistant Professor
Rheumatology, Pediatrics, Pediatric Rheumatology, Internal Medicine
Yu Zuo, MD, MSCS
Assistant Professor
Rheumatology, Internal Medicine
News & Stories
Antiphospholipid antibodies may increase heart disease risk in healthy people
For antiphospholipid syndrome patients, lab results don’t always paint the full picture
Could targeting metabolism treat blood clots in antiphospholipid syndrome?
What I'm Reading in APS Research: June 2026
What I'm Reading in APS Research: April 2026