Age-related Macular Degeneration (AMD or ARMD)
Age-related Macular Degeneration (AMD or ARMD)
What is Age-related Macular Degeneration (AMD)?
Age-related macular degeneration (AMD) is a degenerative eye disease that causes damage to the macula, the central part of the retina at the back of the eye that allows us to see fine details clearly. AMD can impair central vision. People who are affected by AMD may have problems reading, driving and performing activities that require clear central vision. In severe cases, AMD makes close work like threading a needle or reading a book difficult or impossible.
When the macula does not function correctly, we experience blurriness or darkness in the center of our vision. Although AMD reduces vision in the central part of the retina, it does not tend to affect peripheral vision. AMD alone does not usually result in total blindness. Most people continue to have some useful vision and are able to live independently. AMD is the leading cause of irreversible vision loss in our senior population.
Dr. Shah, a retina specialist at the University of Michigan Kellogg Eye Center, discusses Age-related Macular Degeneration (AMD).
Stages of AMD
- The Dry Stage - This is the more common form. In this type of AMD, the delicate tissues of the macula become thinned and slowly lose function over a period of years to decades.
- The Wet Stage - This is less common, but is typically more damaging. The wet type of AMD is caused by the growth of abnormal blood vessels behind the macula. The abnormal blood vessels tend to hemorrhage or leak fluid, resulting in the formation of scar tissue if left untreated. In most instances, the wet stage develops in addition to the dry stage of AMD.
AMD develops differently in each person and the symptoms tend to vary. AMD may cause a progressive loss of central sight; however, it does not usually cause total blindness. Peripheral vision is unaffected, allowing a certain amount of mobility in normal surroundings. If left untreated, the wet type of AMD may progress rapidly.
Appointment Information
For more information or to make an appointment with an eye doctor, call 734-764-4190.
What are the symptoms of AMD?
Some of the symptoms of AMD include:
- Blurry vision
- Distorted vision
- Straight lines appear wavy
- Objects may appear as the wrong shape or size
- The loss of clear, correct colors
- Difficulty reading
- A dark, empty area in the center of vision
The symptoms described above may not necessarily mean that you have AMD. However, if you experience one or more of these symptoms, contact your eye doctor for a complete exam.
How is AMD treated?
Currently, there is no known cure for AMD. There are, however, new therapies emerging. For individuals with AMD, it is recommended that a regular schedule of eye examinations be maintained. During these examinations, your eye doctor may examine your eyes and take special photos of your retinas to help monitor your condition and determine the most appropriate therapy.
Treatment for Dry Macular Degeneration
Supplementation with specific anti-oxidant vitamins and minerals has been shown to significantly slow the progression of dry AMD. For details on the dosage and side-effects, please see your ophthalmologist.
Treatment for Wet Macular Degeneration
Since approximately 2005, ophthalmologists have used a class of drugs called vascular endothelial growth factor (VEGF) inhibitors as the primary treatment for wet macular degeneration. These drugs inhibit the growth and leakage of abnormal blood vessels and are the first treatments that have been shown to improve vision in some eyes rather than simply slowing the rate of vision loss. VEGF inhibitors are delivered through tiny injections in the eye periodically.
Other treatments include laser treatments and photodynamic therapy. These treatments are designed to seal the leaking blood vessels, halting the damage they can inflict upon the retina. These treatments may be effective in slowing the progression of wet macular degeneration and are sometimes used in combination with VEGF inhibitors. Research is underway to find new and more effective treatments for this condition.
Patient Resources
In 2013, the National Eye Institute (NEI) published the results of the Age-Related Eye Disease Study 2 (AREDS2) clinical trial, which was a follow-up to the original AREDS study. The first AREDS study found a 25% reduction in the risk of developing advanced age-related macular degeneration (AMD) over a five-year period in individuals with intermediate AMD, or advanced AMD in one eye, who take a specific formulation of antioxidant vitamins and minerals.
AREDS2 attempted to improve upon the original formulation and found that individuals taking the original AREDS formula with lutein and zeaxanthin but without beta-carotene (vitamin A) may have a slight reduction in the risk of developing advanced AMD. In addition, the formulation without beta carotene may have a lower risk of developing lung cancer in former smokers.
Although the data from the AREDS 2 clinical trial was not strongly conclusive, it provided enough evidence for us to suggest the following formulation if you have intermediate AMD or advanced AMD in one eye:
- Vitamin C 500 mg
- Vitamin E 400 IU
- Zinc 25 to 80 mg
- Copper 2 mg
- Lutein 10 mg
- Zeaxanthin 2 mg
We do not recommend products containing omega 3 fatty acids (DHA and EPA) as they provided no added benefit. Clinical researchers have not studied any other ingredients well enough for us to give recommendations for or against their use. There is no scientific evidence to suggest that the recommended formulation is beneficial in preventing the development of AMD in those without AMD or slowing progression in those with mild AMD.
The nutrients can be consumed individually or through a combination of commercially available products. Many products do not have the exact doses as our recommendation; however, most are within 20% of the recommendations and probably fine.
Although these ingredients are available without a prescription, please consult your eye care professional before starting this treatment.
For more information, visit the National Eye Institute website.
Our low vision team helps individuals with all levels of vision loss to maximize visual function and maintain independence in daily living. Services include peer mentoring, support groups, occupational therapy, rehabilitation, and the use of innovative technologies and devices to support independent living.
Locations
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Ophthalmology Clinic | Brighton Center for Specialty Care 7500 Challis Rd
Entrance 1, Level 2
Brighton, MI 48116-9416Get Directions -
Ophthalmology Clinic | Kellogg Eye Center-Grand Blanc 3181 E Grand Blanc Rd
Grand Blanc, MI 48439-2709Get Directions -
Retina & Uveitis Clinic | Kellogg Eye Center 1000 Wall St
Elevator B Floor 2
Ann Arbor, MI 48105-1912Get Directions
Doctors
Cagri Giray Besirli, MD, PhD
Associate Professor
Ophthalmology
Grant Michael Comer, MD, MS
Clinical Associate Professor
Ophthalmology
Emily Ann Eton, MD
Clinical Assistant Professor
Ophthalmology
Abigail Teich Fahim, MD, PhD
Assistant Professor
Ophthalmology
Thomas Wright Gardner, MD, MS
Professor
Ophthalmology
Michael Jacob Huvard, MD
Clinical Assistant Professor
Ophthalmology
Mark W Johnson, MD
Professor
Ophthalmology
Shilpa Kodati, MBBS
Assistant Professor
Ophthalmology
Jason Matthew Lewis Miller, MD PhD
Assistant Professor
Ophthalmology
Rajesh Chalamalasetty Rao, MD
Associate Professor
Ophthalmology
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