John Robert Charpie, MD, PhD

John R. Charpie, M.D., Ph.D. is Division Director and Amnon Rosenthal Professor of Pediatric Cardiology. In addition, he is Co-Director of the University of Michigan Congenital Heart Center. His clinical interests and expertise are in pediatric cardiac intensive care for infants, children and young adults with congenital and acquired heart disease. Dr. Charpie’s research focuses on myocardial ischemia-reperfusion injury associated with cardiopulmonary bypass and extracorporeal support, and vascular endothelial dysfunction. As a cardiac intensive care physician, Dr. Charpie is also interested in examining early and late outcomes following congenital heart surgical and catheter-based interventions, and developing and testing novel therapies aimed at improving morbidity and mortality including antioxidants and therapeutic hypothermia among others. Dr. Charpie serves as a Principal Investigator or Co-investigator for several government and industry-sponsored studies in pediatric cardiology.

pediatric cardiology, cardiac intensive care, congenital heart disease, pediatric heart disease and congenital heart surgery

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Myocardial ischemia-reperfusion injury
Oxidant stress
Acute and long-term outcomes following congenital heart surgical and catheter-based interventions
Clinical research in congenital and pediatric-acquired heart disease
Vascular endothelial dysfunction and nitric oxide biology