Jason Scott Knight, MD
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About
Dr. Knight received his M.D. and Ph.D. degrees from the University of Michigan and completed his molecular biology Ph.D. research in the laboratory of Dr. Erle Robertson at the University of Pennsylvania. His fellowship in rheumatology was at the University of Michigan, where he pursued postdoctoral research in the laboratory of Dr. Mariana Kaplan. During fellowship, he received the prestigious American College of Rheumatology Distinguished Fellow Award, as well as a Rheumatology Research Foundation Scientist Development Award.
As a faculty member, he has been awarded the Jerome W. Conn Award for Excellence in Research by the Department of Internal Medicine. He has also received the Edmund L. Dubois Award for young lupus researchers from the American College of Rheumatology and the Mary Betty Stevens Young Investigator Prize from the Lupus Foundation of America. He is a member of the American Society for Clinical Investigation.
His NIH-funded research laboratory has also received financial support from the Burroughs Wellcome Fund, Department of Defense, Lupus Research Alliance, and Rheumatology Research Foundation, His research group is working to better understand the triggers and effectors of autoimmunity in lupus and the related antiphospholipid syndrome (APS). His group is also interested in other diseases characterized by excessive neutrophil-mediated inflammation including diabetes and COVID-19.
Dr. Knight is an international leader in the clinical care of APS patients and the role of inflammation in APS. Contact Dr. Knight if you are interested in participating in APS research studies.
Areas of Practice
Systemic Lupus Erythematosus, Antiphospholipid Syndrome
Expertise
Locations
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Rheumatology Clinic | Taubman Center 1500 E Medical Center Dr
Floor 3 Reception A
Ann Arbor, MI 48109-5358Get Directions
Insurance Accepted
University of Michigan Health participates with most health insurance plans.
Education & Training
Medical School or Training
Residency
Fellowships
Board Certifications
Professional Organizations
Research Overview
Interplay between the immune system and thrombosis.
Role of neutrophils and neutrophil extracellular traps (NETs) in autoimmune disease.
Interaction of neutrophils and endothelial cells in antiphospholipid syndrome (APS).
Extracellular purine species as regulators of inflammation in systemic lupus erythematosus (SLE).
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Patient Ratings & Comments
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Patient Ratings
114 Patient Ratings
Patient Comments
February 10, 2026 - "Dr. Knight was very thorough in his consultation, very knowledgeable, patient and personable while answering all of my questions. He really listened to me and cared about choosing the most rational treatment options that would best support my health. He ordered may tests for diagnostic and treatment follow up. I'm grateful for his care and expertise."
January 23, 2026 - "Dr. Knight is wonderful! He is a great listener and provides wonderful explanations to ease my mind."
January 23, 2026 - "Dr. Knight is an excellent, caring, compassionate physician."
December 30, 2025 - "Dr. Knight is very informative and listens. He takes the time and responds back when you have questions. He is the best."
December 5, 2025 - "Dr. Knight is top of the line person and Dr./researcher! I would recommend him to everyone I know [...]! The best of the best"
November 19, 2025 - "I currently have a friend looking for a new Rheumatologist that I plan to recommend Dr. Knight to."
November 7, 2025 - "Dr. Knight is an EXCELLENT Doctor!! He makes you feel like your the only patient he has and he never rushes through the appointment and very thorough!! Highly Recommend!"
October 31, 2025 - "Dr Knight listens so thoroughly and always includes my thoughts in his discussion"
October 14, 2025 - "I feel very fortunate to have Dr. Knight overseeing my care. He is everything you would want in a doctor -- knowledgeable, forward-thinking, approachable, kind, genuine. I really can't say enough good things."
October 13, 2025 - "Dr. Knight is very attentive and knowledgeable. I like to receive his research updates, and we talk a little about It. He is a great doctor."
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