Brett McCray, MD, PhD

Charcot-Marie-Tooth Disease, Hereditary Neuropathy, Peripheral Neuropathy

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Dr. Brett McCray is a physician-scientist with a clinical and research focus on hereditary neuropathies, including Charcot-Marie-Tooth (CMT) disease, as well as other forms of peripheral neuropathy. In addition to caring for patients with CMT and other neuromuscular diseases, he runs a basic science and translational lab focused on the pathogenesis of inherited neuropathy with the goal of identifying common pathogenic mechanisms and novel broadly applicable therapeutic targets. His current work is focused on understanding the pathogenesis of CMT type 2C, which is caused by mutations in the calcium-permeable cation channel TRPV4. His lab studies cellular and animal models of the disease, and he has also established a TRPV4 patient registry and natural history study to pave the way for a future clinical trial.