Nail-Patella Syndrome (NPS)

Nail-Patella Syndrome (NPS)

  • Overview
  • Appointments
  • Symptoms
  • Treatments
  • Locations
  • Doctors

    • What is nail-patella syndrome (NPS)?

    Nail-Patella syndrome (NPS) is a rare genetic disorder that causes abnormalities of bone, joints, fingernails, kidneys, and glaucoma. NPS is characterized by absent or under-developed kneecaps and thumbnails. It is estimated to occur in 1 in 50,000 newborns.

    What causes NPS?

    Nail-Patella Syndrome is caused by the alteration, or mutation, of a gene that makes a protein necessary for normal development of the limbs, eyes, and kidneys.

    Appointment Information

    For more information or to make an appointment, call 734-764-4190.

    What are the symptoms of NPS?
    • Loss of peripheral (side) vision
    • Blind spots
    • Need for frequent changes in glasses
    • Difficulty in adjusting to a dark room
    • Blurred vision
    • Sore, reddened eyes
    • Appearance of halos or rainbows around lights
    • Severe headaches, nausea and eye pain in rare cases

    How is NPS treated?

    The treatment for NPS and glaucoma depends upon the severity of each case. In general, glaucoma cannot be cured, but it can be controlled. Glaucoma medications (either eye drops or pills), laser procedures, and surgical operations are used to slow further damage from occurring. With any type of glaucoma, periodic examinations are very important to prevent vision loss. Because glaucoma can worsen without your being aware of it, treatment may need to be changed over time.

    Locations
    • Glaucoma Clinic | Kellogg Eye Center 1000 Wall St
      Elevator B Floor 2
      Ann Arbor, MI 48105-1912       Get Directions
    • Ophthalmology Clinic | Brighton Center for Specialty Care 7500 Challis Rd
      Entrance 1, Level 2
      Brighton, MI 48116-9416       Get Directions
    • Ophthalmology Clinic | Canton Health Center 1051 N Canton Center Rd
      Canton, MI 48187-5097       Get Directions
    • Ophthalmology Clinic | Kellogg Eye Center-Grand Blanc 3181 E Grand Blanc Rd
      Grand Blanc, MI 48439-2709       Get Directions
    • Ophthalmology Clinic | Northville Health Center 39901 Traditions Dr
      Floor 2
      Northville, MI 48168-9493       Get Directions
    • Ophthalmology Clinic | River Place Office Building 1974 N Huron River Dr
      River Place Offices
      Ypsilanti, MI 48197-1654       Get Directions

    Doctors

     Search for a U-M Health doctor     Amanda Bicket, MD

    Amanda K Bicket, MD

    Assistant Professor

    Ophthalmology

    Joshua Robert Ehrlich, MD

    Joshua Robert Ehrlich, MD, MPH

    Associate Professor

    Ophthalmology

    Joshua Robert Ehrlich, MD

    Joshua Robert Ehrlich, MD, MPH

    Associate Professor

    Ophthalmology

    Angela Elam, MD

    Angela Renee Elam, MD, MPH

    Assistant Professor

    Ophthalmology, Oculoplastics Ophthalmology

    Charles R. Frank

    Charles Ross Frank, MD

    Clinical Assistant Professor

    Ophthalmology

    Denise Ann-Marie John, MD, FRCSC

    Clinical Associate Professor

    Ophthalmology

    Andrew Kalina, MD

    Andrew Kalina, MD

    Clinical Assistant Professor

    Ophthalmology

    Paul Pue-Jung Lee, MD, JD

    Professor

    Ophthalmology

    Paul R Lichter, MD, MS

    Clinical Professor Emeritus

    Ophthalmology

    Paula Anne Newman-Casey, MD

    Paula Anne Newman-Casey, MD, MS

    Associate Professor

    Ophthalmology

    Show All Doctors

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