What is hemophilia?
In hemophilia, blood does not clot properly. This usually happens because your body does not have enough of a certain kind of clotting factor. This makes it harder for bleeding to stop. People with hemophilia may bleed a lot after cuts, during surgery, or even after a fall. Some people have abnormal bleeding inside their bodies for no clear reason.
There are two main types of hemophilia:
- Hemophilia A is caused by a lack of active clotting factor VIII (8). About 1 out of every 5,000 male babies is born with hemophilia A. footnote 1
- Hemophilia B (Christmas disease) is caused by a lack of active clotting factor IX (9). It is less common and affects 1 out of 30,000 male babies. footnote 1
Hemophilia usually runs in families and almost always affects males. In rare cases, a person may get a type that does not run in the family. This is called acquired hemophilia, and it affects both males and females.
What causes hemophilia?
Hemophilia A and B are caused by a flaw in a part of a gene. This flaw affects how much clotting factor a person has and how well it works.
With acquired hemophilia, clotting factors don't work right because the body makes antibodies that attack them.
What are the symptoms?
Symptoms of hemophilia include:
- Bleeding into a joint or muscle, which causes pain and swelling.
- Bleeding that is not normal after an injury or surgery.
- Easy bruising.
- Frequent nosebleeds.
- Blood in the urine.
- Bleeding after dental work.
Some people with milder types of the disease may not have symptoms until later in life. But most of the time, hemophilia symptoms are noticed during infancy or childhood. Symptoms noticed in infants include:
- Bleeding into the muscle, which causes a deep bruise after the baby gets a routine vitamin K shot.
- Bleeding that goes on for a long time after the infant's heel is pricked to draw blood for newborn screening tests.
- Bleeding that goes on for a long time after a baby is circumcised.
- Bleeding in the scalp or brain after a difficult delivery or after special devices (vacuum or forceps) are used to help deliver the baby.
How is hemophilia diagnosed?
If your doctor thinks that you or your child may have a problem with blood clotting, he or she will take a blood sample. The sample will be used in tests that check for the amount of clotting factor. If the level is low, then more tests will find out the type of hemophilia and how severe it is.
How severe the disease is depends on how much clotting factor is produced and when bleeding most often occurs.
- Mild hemophilia: Clotting factor level is at least 5% of normal. This type might not be noticed unless there is a lot of bleeding after a major injury or surgery.
- Moderate hemophilia: Clotting factor level is 1% to 5% of normal. Bleeding normally follows a fall, sprain, or strain.
- Severe hemophilia: Clotting factor level is less than 1% of normal. Bleeding often happens one or more times a week for no reason.
If hemophilia runs in your family and you are planning to have children, ask your doctor about tests that can show if you are a carrier. (Only females can be carriers.) This will allow you to make informed decisions about pregnancy and prenatal care.
How is it treated?
Hemophilia can be treated by replacing missing blood clotting factors. This is called clotting factor replacement therapy. Clotting factor concentrate is injected into a vein. Replacement therapy can prevent or treat bleeding episodes.
You may need to take medicines, such as desmopressin (for example, DDAVP or Stimate), that help prevent bleeding. You might take medicines at certain times, such as before you have surgery or dental work. Some people also need pain medicine to help with pain from joint damage.
You can live a normal life with treatment. Hemophilia treatment centers are available at most large medical centers. They are an excellent resource to help you and your family get the best care for this condition.
What can you do at home?
You can take steps at home to prevent bleeding episodes and improve your health.
- Learn how to recognize bleeding episodes so you can start treatment right away.
- Stay at a healthy weight. Additional stress on joints can trigger bleeding episodes.
- Exercise with care. Choose activities, such as swimming, that do not put too much pressure on your joints.
- Don't take nonprescription medicines unless your doctor tells you to. And don't take aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen. These can affect the clotting action of your blood.
- Prevent injuries and accidents around your home.
- Chitlur M, Kulkarni R (2015). Hemophilia and related conditions. In ET Bope, RD Kellerman, eds., Conn's Current Therapy 2015, pp. 846–853. Philadelphia: Saunders.
Other Works Consulted
- Chitlur M, Kulkarni R (2013). Hemophilia and related conditions. In ET Bope, RD Kellerman, eds., Conn's Current Therapy 2013, pp. 803–810. Philadelphia: Saunders.
- Friedman KD, Rodgers GM (2009). Inherited coagulation disorders. In JP Greer et al., eds., Wintrobe's Clinical Hematology, 12th ed., vol. 2, pp. 1379–1424. Philadelphia: Lippincott Williams and Wilkins.
- Hillman RS, et al. (2011). Hemophilia and other intrinsic pathway defects. In RS Hillman et al., eds., Hematology in Clinical Practice, 5th ed., pp. 398–410. New York: McGraw-Hill.
- Roberts HR, et al. (2010). Hemophilia A and hemophilia B. In K Kaushansky et al., eds., Williams Hematology, 8th ed., pp. 2009–2029. New York: McGraw-Hill.
- Srivastava A, et al. (2013). Guidelines for the management of hemophilia. Haemophilia, 19(1): e1–e47. Also available online: http://www.wfh.org/en/page.aspx?pid=1270.
Current as of: September 23, 2020
Author: Healthwise Staff
E. Gregory Thompson MD - Internal Medicine
Adam Husney MD - Family Medicine
Martin J. Gabica MD - Family Medicine
Brian Leber MDCM, FRCPC - Hematology
Current as of: September 23, 2020
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