Royal Jelly


Royal jelly is a thick, milky substance produced by worker bees to feed the queen bee. The worker bees mix honey and bee pollen with enzymes in the glands of their throats to produce royal jelly.

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used forWhy
2 Stars
High Cholesterol
150 to 6,000 mg daily
Supplementing with royal jelly may improve cholesterol levels.
contains various sugars, proteins, and medium-chain fatty acids and has demonstrated antioxidant and anti-inflammatory properties. Royal jelly was found to lower total, LDL-, and non-HDL cholesterol levels in subjects with type 2 diabetes in a meta-analysis of findings from 12 randomized controlled trials. In a placebo-controlled trial in 40 subjects with mildly elevated cholesterol levels, 3,150 mg royal jelly daily resulted in an 11.5% reduction in total cholesterol levels and a 4.8% reduction in LDL-cholesterol levels. In an eight-week placebo-controlled trial with 60 healthy overweight participants, 666 mg of royal jelly per day was found to lower total cholesterol levels and improve antioxidant status. A small controlled trial in 15 healthy volunteers found 6 grams of royal jelly per day for four weeks reduced total and LDL-cholesterol levels. In an uncontrolled trial, 36 healthy postmenopausal women received 150 mg of a high-potency royal jelly product daily for three months; at the end of the trial, HDL-cholesterol levels had increased by 7.7%, total cholesterol levels had decreased by 3.09 %, and LDL-cholesterol levels had decreased by 4.1%.

How It Works

How to Use It

Royal jelly in the amount of 50–100 mg per day has been used in most of the studies on cholesterol lowering.

Where to Find It

Royal jelly is available in liquid form (usually in glass vials), tablets, and capsules.

Possible Deficiencies

Because royal jelly is not an essential nutrient, deficiencies do not occur.


Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Side Effects

Allergic reactions are the most common side effect. Allergic reactions from oral intake of royal jelly can range from very mild (e.g., mild gastrointestinal upset) to more severe reactions, including asthma, anaphylaxis (shock), intestinal bleeding, and even death in people who are extremely allergic to bee products.1, 2, 3 People who are allergic to bee pollen, honey, or conifer and poplar trees should not use royal jelly orally. Topical use of royal jelly has been reported to cause skin irritations in some people.4


1. Thien FCK, Leung R, Baldo BA, et al. Asthma and anaphylaxis induced by royal jelly. Clin Exp Allergy 1996;26:216–22.

2. Leung R, Ho A, Chan J, et al. Royal jelly consumption and hypersensitivity in the community. Clin Exp Allergy 1997;27:333–6.

3. Yonei Y, Shibagaki K, Tsukada N, et al. Case report: haemorrhagic colitis associated with royal jelly intake. J Gastroenterol Hepatol 1997;12:495–9.

4. Takahashi M, Matsuo I, Ohkido M. Contact dermatitis due to honeybee royal jelly. Contact Dermatitis 1983;9:452–5.

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