Histidine is called a semi-essential amino acid (protein building block) because adults generally produce adequate amounts but children may not. Histidine is also a precursor of histamine, a compound released by immune system cells during an allergic reaction.

How It Works

How to Use It

Most people do not need to supplement histidine. Optimal levels for others remain unknown. Human research has used between 1 gram and 8 grams per day.

Where to Find It

Dairy, meat and poultry, and fish are good sources of histidine.

Possible Deficiencies

According to limited research, many people with rheumatoid arthritis have low levels of histidine. Taking histidine supplements might improve arthritis symptoms in some people.1


Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Side Effects

No side effects have been reported with histidine. However, people with kidney or liver disease should not consume large amounts of amino acids without consulting a healthcare professional.


1. Gerber DA, Gerber MG. Specificity of a low free histidine concentration for rheumatoid arthritis. J Chronic Dis 1977;30:115-27.

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