Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
3 StarsReliable and relatively consistent scientific data showing a substantial health benefit.
2 StarsContradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1 StarFor an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
This supplement has been used in connection with the following health conditions:
Seaweed extract in an amount providing 2.4 to 3.0 mg of fucoxanthin per day
Fucoxanthin, an antioxidant found naturally in some types of seaweed, might prevent the growth of fat tissue and reduce abdominal fat.
Fucoxanthin is a member of the carotenoid family, and is found naturally in some types of seaweed, such as wakame. Laboratory studies suggest fucoxanthin reduces inflammation and oxidative stress and may inhibit dietary fat absorption by inhibiting fat-digesting enzymes known as lipases. It also appears to improve lipid metabolism and increase fat burning. In a placebo-controlled trial, 151 premenopausal non-diabetic women with obesity took either a supplement providing 300 mg of seaweed extract (providing 2.4 mg of fucoxanthin) plus 200 mg of pomegranate oil, or placebo daily for 16 weeks; those taking the supplement had greater reductions in body weight, body fat, liver fat, waist circumference, triglyceride levels, and levels of the inflammatory marker C-reactive protein. The same supplement, taken in in amount providing 3 mg of fucoxanthin per day, was reported to change the character of adipose tissue in two subjects to a type associated with increased heat production and energy expenditure.
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1. Yan X, Chuda Y, Suzuki M, Nagata T. Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed. Biosci Biotechnol Biochem 1999;63:605-7.
2. Sachindra NM, Sato E, Maeda H, et al. Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites. J Agric Food Chem 2007;55:8516-22.
3. Maeda H, Hosokawa M, Sashima T, et al. Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin. J Oleo Sci 2007;56:615-21.
4. Maeda H, Hosokawa M, Sashima T, Miyashita K. Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice. J Agric Food Chem 2007;55:7701-6.
5. Maeda H, Hosokawa M, Sashima T, et al. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun 2005;332:392-7.
6. Yoshiko S, Hoyoku N. Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45 gene expression in human cancer cells. In Vivo 2007;21:305-9.
7. Sugawara T, Matsubara K, Akagi R, et al. Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol. J Agric Food Chem 2006;54:9805-10.
8. Nishino H, Murakosh M, Ii T, et al. Carotenoids in cancer chemoprevention. Cancer Metastasis Rev 2002;21:257-64 [review].
9. Shiratori K, Ohgami K, Ilieva I, et al. Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Exp Eye Res 2005;81:422-8.
10. Asai A, Yonekura L, Nagao A. Low bioavailability of dietary epoxyxanthophylls in humans. Br J Nutr 2008 Jan 11;:1-5 [Epub ahead of print].
Last Review: 03-24-2015
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2022.