Neratinib Oral Tablet (NERATINIB - ORAL)

For treating cancer.

Brand Name(s): Nerlynx

Generic Name: Neratinib

Instructions

Swallow the medicine without crushing or chewing it.

Take the medicine with food.

This medicine will work best if you take it at about the same time every day.

Store at room temperature away from heat, light, and moisture. Do not keep in the bathroom.

Please ask your doctor, nurse, or pharmacist how to discard unused medicines safely.

Drink extra water while on this medicine. Adults should try to drink 6-8 cups (48 to 64 oz.) of water every day.

Avoid grapefruit juice while on this medicine.

Do not take this medicine with antacids.

Medicines that lower stomach acid (used to treat indigestion, heartburn or ulcers) may prevent this medicine from working properly.

If you forget a dose, just wait. Use the next dose at the usual time. Do not use 2 doses at once.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

Avoid touching any powder from a broken tablet. If the powder touches the skin, nose, or eyes, rinse thoroughly with water.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

May cause mouth sores. Brush teeth gently. Avoid products containing alcohol. Rinse mouth with a mixture of water and baking soda or salt.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

Do not use the medication any more than instructed.

Please tell your doctor if you have moderate to severe diarrhea while on this medicine. Do not treat the diarrhea with over-the-counter diarrhea medicine.

Do not breastfeed while on this medicine. You may safely start breastfeeding 1 month after stopping treatment.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Women must use reliable forms of birth control while taking this medicine and for 1 month after stopping to prevent pregnancy.

Men with a female partner who is of childbearing age must use reliable birth control during sexual activity while taking this medicine and for 3 months after stopping to prevent pregnancy.

Do not take St. John's wort while on this medicine.

Women who are pregnant or in their childbearing years should not touch or handle this medicine. This medicine can be absorbed through the woman's skin and harm the unborn baby.

Do not share this medicine with anyone who has not been prescribed this medicine.

Always refill this medicine before it runs out.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

  • decreased appetite
  • diarrhea
  • lack of energy and tiredness
  • mouth sores or irritation
  • muscle cramps
  • nausea and vomiting
  • dry skin
  • stomach upset or abdominal pain
  • weight loss

Call your doctor or get medical help right away if you notice any of these more serious side effects:

  • severe or persistent abdominal pain
  • severe, watery or bloody diarrhea
  • dizziness
  • fast or irregular heart beats
  • pain in the joints
  • signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
  • muscle aches, spasms or abnormal movements
  • red, burning, or itchy skin
  • shortness of breath
  • red, peeling or blistering skin
  • persistent or unusual thirst
  • urinating less often
  • dark urine
  • severe or persistent vomiting
  • unexpected or extreme weight loss

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.

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