Pronunciation: PROE poe fol

Brand: Diprivan, Propoven

What is the most important information I should know about propofol?

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

What is propofol?

Diprivan is used to help you relax before and during general anesthesia for surgery or other medical procedures.

Diprivan is used in people 16 years or older to sedate those who are under critical care and need a mechanical ventilator (breathing machine).

Diprivan is not recommended for induction of anesthesia in people younger than 3 years and for the maintenance of anesthesia in people younger than 2 months.

The US Food and Drug Administration (FDA) has authorized emergency use of Propoven to maintain sedation in people who are 16 years or older on a machine that helps with breathing (ventilator) in the intensive care unit (ICU) during the Coronavirus Disease 2019 (COVID-19) Pandemic.

Propofol may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before I receive propofol?

You should not use propofol if you are allergic to it, or if you have:

  • allergies to peanuts, eggs, egg products, soybeans or soy products.

Tell your doctor if you have ever had:

  • liver or kidney disease;
  • epilepsy or other seizure disorder; or
  • high cholesterol or triglycerides (a type of fat in the blood).

Anesthesia may affect brain development in a young child or unborn baby (when used in the mother), leading to learning or behavior problems later in life. Long surgeries or repeated procedures pose the highest risks.

Tell your doctor if you are pregnant or breastfeeding.

How is propofol given?

Propofol is injected into a vein by a healthcare provider.

You will relax and fall asleep very quickly after propofol is injected.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely.

What happens if I miss a dose?

Propofol is used when needed and does not have a daily dosing schedule.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid after receiving propofol?

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

What are the possible side effects of propofol?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your medical caregivers right away if you have:

  • a light-headed feeling (like you might pass out) even after feeling awake;
  • weak or shallow breathing; or
  • severe pain or discomfort where the injection is given.

Common side effects may include:

  • mild itching or rash;
  • fast or slow heart rate; or
  • slight burning or stinging around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect propofol?

It may take you longer to recover from anesthesia if you use other drugs that make you sleepy or slow your breathing. This includes opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Other drugs may affect propofol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Your doctor or pharmacist can provide more information about propofol.

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