Preeclampsia: Creatinine Clearance Test

NOTICE: This health information was not created by the University of Michigan Health System (UMHS) and may not necessarily reflect specific UMHS practices. For medical advice relating to your personal condition, please consult your doctor. Complete disclaimer

Preeclampsia: Creatinine Clearance Test

Topic Overview

When muscles use energy, they release a waste product called creatinine into the blood. The kidneys then filter creatinine from the blood. From the kidneys, creatinine passes out of the body through the urinary tract. If the kidneys are not functioning normally, high amounts of creatinine remain in the blood while low amounts are passed out in the urine.

During a normal pregnancy, increased blood volume and kidney function cause an increase in the amount of creatinine filtered out of the blood and passed into the urine. A measurement of this amount is called the creatinine clearance value. If the kidneys are damaged by preeclampsia, the creatinine clearance value decreases because the kidneys are filtering less creatinine out of the blood. The amount of kidney damage can be estimated by the amount of decrease in the creatinine clearance value.

The creatinine clearance test requires a blood sample and a sample of all the urine collected for 24 hours (24-hour urine sample).

For more information, see the topic Creatinine and Creatinine Clearance.

Related Information

Credits

By Healthwise Staff
Primary Medical Reviewer Sarah Marshall, MD - Family Medicine
Specialist Medical Reviewer William Gilbert, MD - Maternal and Fetal Medicine
Current as of June 4, 2014

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

© 1995-2014 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.