Mark Edward P Prince MD

Professor, Otolaryngology
Clinical Interests:

Head and neck cancer, facial plastic and reconstructive surgery, salivary gland tumors, thyroid and parathyroid surgery, microvascular free tissue reconstructive surgery, medical student/resident and fellow education

Video profile


U of M Otolaryngology

Taubman Center Floor 1 Reception A
1500 E Medical Center Dr SPC 5312
Ann Arbor


Medical School or Training

  • Dalhousie University School of Medicine, 1988


  • Dalhousie University School of Medicine, Surgery General, NS, 1992

  • Dalhousie University School of Medicine, Otolaryngology, NS, 1996


  • Adv Head & Neck Oncology & Microvascular Reconstructive Surg, University of Michigan Health System, 1998

Professional Organizations

  • American Board of Otolaryngology

  • American Academy of Otolaryngology

  • American Head and Neck Society

  • American Association of Cancer Researchers

  • Royal College of Physicians and Surgeons of Canada

Board Certification

  • Otolaryngology


cancer stem cells in head and neck cancer (first to isolate cancer stem cells from head and neck squamous cell cancer), cancer stem cell tumor vaccines, head and neck cancer metastasis, HPV infection in HNSCC


Dr. Mark Prince earned his medical degree at Dalhousie University Medical School in Halifax, Nova Scotia, and then served with the Canadian Armed Forces as a medical officer, receiving specialized training in hyperbaric and diving medicine. Dr. Prince returned to Dalhousie University and completed a residency in otolaryngology head and neck surgery, followed by a two-year fellowship in advanced head and neck oncology and microvascular reconstructive surgery at the University of Michigan. He joined the University of Michigan faculty in 2000, and is actively involved in resident and medical student education, serving as his department's residency program director. Dr. Prince served as the chief of the section of otolaryngology at the Ann Arbor VA Medical Center until 2009, he continues to serve there as an active staff member. His research laboratory published the first report of the identification of cancer stem cells in head and neck squamous cell cancer, and continues to conduct research in this exciting field.