Medical School or Training
University of Michigan Medical School, 2007
University of Michigan Health System, Internal Medicine, MI, 2010
Internal Medicine Rheumatology, University of Michigan Health System, 2012
Recent evidence suggests that neutrophil extracellular trap (NET) formation (the extracellular release of chromatin fibers in complex with granular antimicrobial proteins) stimulates IFN-α production in lupus. NETs are also directly toxic to the vasculature in human lupus, as well as in murine models of sepsis. I plan to study both human and murine models to better understand the dynamic role of NET formation in lupus vasculopathy. I am also interested in the more global role of NET formation in lupus pathogenesis.