Medical School or Training
Xiangya Medical School, Central South University, 1995
Xiangya Hospital, Cardio-thoracic Surgery, 1998
University of Arizona Cancer Center, Surgery General, AZ, 2008
Cardiothoracic Surgery, Stanford University Medical Center, 2011
The mechanisms of thoracic aortic aneurysmal formation in bicuspid aortic valve patients (BAV) and Familial Aortic Aneurysm (FAA), is not well understood. Currently thoracic aneurysms are repaired electively and occasionally emergently. Various materials are used for aneurysm repair including Dacron grafts and stent grafts made of PTFE, These materials, while durable, are far from ideal.
With these realities, my research interest is to establish the human BAV-disease model with state-of-art induced pluripotent stem (iPS) cell technology and study the mechanism of aneurysmal formation in BAV patients as well as to generate patient specific, tissue engineered, vascular grafts using iPS cells combined with fabricated nanofibrous materials.
Our research team is a collaborative group including the disciplines of cardiac surgery, vascular biology and bioengineering as well as other basic and clinical scientists.
Bo Yang, MD, Ph.D. joined the Department of Cardiac Surgery at the University of Michigan July 2011 after completing his General surgery residency at the University of Arizona and Cardiothoracic surgery fellowship at Stanford University. His clinical interests span the range of complex adult cardiac surgical procedures including valve repair and replacement, aortic dissections and aneurysms, coronary artery disease as well as transplantation and mechanical circulatory support. His research interests currently focus on patient specific tissue engineered vascular grafts or conduits utilizing induced pluripotent stem cells, as well as research interests in the mechanisms of aneurysm formation, and diastolic heart failure.