collagenase clostridium histolyticum

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collagenase clostridium histolyticum

Pronunciation: KOL a JEN ase klos TRID ee um HIS toe LIT ik um

Brand: Xiaflex

What is the most important information I should know about collagenase clostridium histolyticum?

Multum calldoc

Collagenase clostridium histolyticum can damage a nerve, tendon, or ligament in the hand the medicine is injected into. After the swelling from your injection goes down, call your doctor if you have numbness, tingling, increased pain, trouble bending your finger toward your wrist, or if you have new or worsened movement problems in your treated hand.

What is collagenase clostridium histolyticum?

Collagenase clostridium histolyticum is made from a mixture of proteins derived from a certain bacteria.

Collagenase clostridium histolyticum is used to treat Dupuytren's contracture in adults. This condition causes an abnormal thickening of the tissue in the palm of the hand. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.

Collagenase clostridium histolyticum may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before receiving collagenase clostridium histolyticum?

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You should not use collagenase clostridium histolyticum if you are allergic to it.

Collagenase clostridium histolyticum can damage a nerve, tendon, or ligament in the hand the medicine is injected into. This damage can weaken your hand and may lead to a broken bone or other problems. Surgery may be needed to correct these conditions. Talk to your doctor if you are concerned about this risk.

To make sure collagenase clostridium histolyticum is safe for you, tell your doctor if you have:

  • a bleeding or blood clotting disorder, such as hemophilia; or
  • if you take a blood thinner such as aspirin, prasugrel (Effient), or warfarin (Coumadin, Jantoven).

FDA pregnancy category B. It is not known whether collagenase clostridium histolyticum will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

It is not known whether collagenase clostridium histolyticum passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is collagenase clostridium histolyticum given?

This medication is injected directly into the "cord" of the affected hand. A healthcare provider will give you this injection.

Multum donot

After your injection, do not touch or put pressure on the treated area of the hand for the rest of the day. Keep the treated hand elevated until bedtime.

The day after your injection, your doctor will need to examine your hand to see if your condition has improved. If you still have the cord, your doctor may try to break it by extending your treated finger.

Collagenase clostridium histolyticum is usually given once every 4 weeks and you may receive more than one injection at a time. Follow your doctor's dosing instructions very carefully.

You may need to wear a splint on your hand for a short time to keep your fingers straight, especially at night. You may also need to perform daily finger exercises. Follow your doctor's instructions.

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Call your doctor if you have trouble bending the treated finger after the swelling goes down.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your collagenase clostridium histolyticum injection.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid before and after receiving collagenase clostridium histolyticum?

Multum donot

Until you visit your doctor the day after your injection, do not flex or extend the fingers of your treated hand. Doing so may cause the medicine to spread away from the treatment area, making it less effective.

Avoid any strenuous activity using the treated hand until your doctor tells you to resume normal activities.

What are the possible side effects of collagenase clostridium histolyticum?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have:

  • numbness, tingling, or increased pain in the treated hand;
  • trouble bending your finger toward your wrist;
  • new or worsened movement problems in your treated hand;
  • signs of infection such as fever, chills, redness or swelling;
  • severe pain, itching, or other irritation; or
  • feeling like you might pass out (even while lying down).

Common side effects may include:

  • swelling, bruising, or bleeding where the medicine was injected;
  • mild pain or tenderness in the treated hand;
  • swollen glands in your elbow or underarm;
  • itching, redness, or warmth of the skin;
  • cracked skin; or
  • underarm pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs can affect collagenase clostridium histolyticum?

Other drugs may interact with collagenase clostridium histolyticum, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about collagenase clostridium histolyticum.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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