My research centers on the mechanistic aspects of lung inflammation, antimicrobial defense, and fibrosis. Using tools of molecular and cell biology, cells from diseased patients, as well as animal models of disease, we focus on the functions of two key cells in the lung, macrophages and fibroblasts, and how these cells interact with each other and with neighboring epithelial cells. Ongoing current projects include: 1) the role of extracellular vesicles in cell-cell communication in lung health and disease, and 2) cellular programs dictating aberrant fibroblast activation in pulmonary fibrosis. We are currently examining disease states including asthma, cigarette smoke-induced inflammation, lung cancer, lung infection, and idiopathic pulmonary fibrosis. Our ultimate goal is to gain novel insights into lung homeostasis and disease pathogenesis, and to identify new strategies for therapeutic targeting. The laboratory consists of a highly interactive and collaborative group of students as well as M.D. and Ph.D. postdoctoral trainees from around the world.