Hyaluronic acid is a member of the family of molecules known as glycosaminoglycans. This family also includes chondroitin sulfate and some other large carbohydrate-containing molecules. Hyaluronic acid is an important component of the connective tissue that fills the spaces between cells of the skin and other tissues, and is a major ingredient of the synovial fluid that lubricates and cushions joints as well as the vitreous humor that fills the inner chamber of the eye.1
Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
3 StarsReliable and relatively consistent scientific data showing a substantial health benefit.
2 StarsContradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1 StarFor an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
This supplement has been used in connection with the following health conditions:
Apply five times per day for one week or twice per day for three weeks
Gels and sprays containing hyaluronic acid, an important connective tissue component in the gums, have been shown to help reduce bleeding tendency and other indicators of gingivitis.
is an important connective tissue component in the gums. Double-blind studies of topical hyaluronic acid treatments have shown that applying either a gel twice a day or a spray five times per day to the gum tissues helps reduce bleeding tendency and other indicators of gingivitis. However, plaque removal is still necessary for best results, and one study found that adding weekly topical hyaluronic acid treatments to a single session of scaling and root planing did not make a significant difference in healing. No research has investigated whether hyaluronic acid supplements that are swallowed are effective for treating gingivitis.
Apply a gel containing a partial benzyl ester derivative of hyaluronan under compression bandaging daily
A trial found that topical application of a hyaluronic acid compound with compression bandaging was significantly better than bandaging alone for healing chronic venous skin ulcers.
A controlled trial found that topical application of a compound with compression bandaging was significantly better than bandaging alone for healing chronic venous skin ulcers.No research has investigated whether oral hyaluronic acid supplements might be similarly effective.
1% solution for ears
Topically applied hyaluronic acid is sometimes used in skin wound dressings to improve healing.
Topical application of and related compounds is sometimes used in skin wound dressings to improve healing. One controlled trial found a hyaluronic acid compound helpful for healing skin ulcers associated with chronic venous insufficiency. Improved healing of nasal surgery wounds with topical hyaluronic acid was reported in one controlled study, but not in another. A double-blind study found improved healing of perforated eardrums in patients using drops of 1% sodium hyaluronate. Whether oral hyaluronic acid supplements might improve wound healing has not been investigated.
Refer to label instructions
Injection of hyaluronic acid compounds into osteoarthritic joints, primarily the knee, has been shown to improve symptoms.
is a normal component of joint fluid, but its amount and molecular structure are altered in osteoarthritic joints. Injection of hyaluronic acid compounds into osteoarthritic joints, primarily the knee, has been investigated in many double-blind trials with some improvement demonstrated. However, no research has been done to determine whether oral supplementation with hyaluronic acid is an effective treatment for osteoarthritis.
How It Works
How to Use It
Amounts for oral supplementation have not been established, due to lack of research, and it is unknown whether hyaluronic acid can be absorbed from the gastrointestinal tract. Topical products are applied in the mouth two or more times per day, to the nose three to four times per day, or with bandaging for skin ulcers. Eye drops containing 0.1 to 0.4% sodium hyaluronate are used three or more times per day, and ear drops containing 1% sodium hyaluronate are used once a day.
Where to Find It
Hyaluronic acid is produced in the human body and is found in the tissues of all animals. A nonanimal source of hyaluronic acid can be synthesized by bacterial fermentation.
Hyaluronic acid is produced naturally in the human body and is not considered an essential nutrient. However, hyaluronic acid levels in osteoarthritic joints are below normal.2
Interactions with Supplements, Foods, & Other Compounds
Interactions with Medicines
A controlled study reported that males taking 600 mg per day of hyaluronic acid for four weeks had higher blood levels of the enzyme alkaline phosphatase.3 The significance of this finding is unclear.
There have been anecdotal reports of skin rash following oral supplementation with hyaluronic acid.4
1. Laurent TC, Fraser JR. Hyaluronan. FASEB J 1992;6:2397-404.
2. Tehranzadeh J, Booya F, Root J. Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Acta Radiol2005;46:288-96 [review].
3. Bates B. Supplements trigger potassium, alkaline phosphatase changes. Skin and Allergy News 2003;July:43.
4. Sahelian R. Hyaluronic acid supplement side effects, benefit, allergy, toxicity, adverse events, and medical benefits for joint health information. [Cited 2006 May 13]. Available from URL: http://www.raysahelian.com/hyaluronic-acid.html.
Last Review: 06-08-2015
Copyright © 2023 TraceGains, Inc. All rights reserved.
The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2023.