Botanical names:
Gymnema sylvestre

Parts Used & Where Grown

Gymnema sylvestre is a woody climbing plant that grows in the tropical forests of central and southern India. The leaves are used in herbal medicine preparations. G. sylvestre is known as "periploca of the woods" in English and meshasringi (meaning “ram’s horn”) in Sanskrit. The leaves, when chewed, interfere with the ability to taste sweetness, which explains the Hindi name gurmar—“destroyer of sugar.”

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used forWhy
2 Stars
Type 1 Diabetes
400 mg daily
Gymnema may help normalize blood sugar control in people with type 1 diabetes.
Test tube and animal studies have found several mechanisms by which gymnema (Gymnema sylvestre) may help normalize blood sugar control in people with diabetes, including reducing glucose absorption in the intestines, and stimulating regeneration and activity of pancreatic cells that release insulin. In a controlled trial with people with type 1 diabetes, 400 mg per day of gymnema extract improved blood glucose control and reduced requirements for insulin. Some practitioners recommend using gymnema extracts standardized for their content of active constituents called gymnemic acids. Gymnema is not a substitute for insulin, but insulin amounts may need to be lowered in order to avoid hypoglycemia while taking gymnema.
2 Stars
Type 2 Diabetes
400 to 1,000 mg daily
Gymnema may stimulate the pancreas to produce insulin and help normalize blood glucose control in people with type 2 diabetes.
Gymnema has a long history of traditional use treating diabetes, and studies suggest gymnema and its active component, gymnemic acid, have anti-diabetes effects including reducing glucose absorption, stimulating the pancreas to produce insulin, and lowering triglyceride accumulation. So far, no double-blind trials have confirmed the efficacy of gymnema to treat diabetes. However, in preliminary studies, doses of 400 mg, 500 mg, and 1 gram per day of gymnema extract have been found to reduce blood glucose levels, increase insulin production, and improve markers of glycemic control in people with type 2 diabetes, in some cases allowing study participants to reduce their use of diabetes medications. Gymnema is not a substitute for insulin therapy, but insulin doses may need to be lowered while taking gymnema to avoid hypoglycemia.

Traditional Use (May Not Be Supported by Scientific Studies)

Gymnema has been used in India for the treatment of type 1 and type 2 diabetes for over 2,000 years. The leaves were also used for stomach ailments, constipation, water retention, and liver disease.

How It Works

Botanical names:
Gymnema sylvestre

How It Works

The hypoglycemic (blood sugar-lowering) action of gymnema leaves was first documented in the late 1920s.1 This action is attributed to members of a family of substances called gymnemic acids.2, 3 Gymnema leaves raise insulin levels, according to research in healthy volunteers.4 Based on animal studies, this may be due to regeneration of the cells in the pancreas that secrete insulin,5, 6 or by increasing the flow of insulin from these cells.7 Other animal research shows that gymnema can also reduce glucose absorption from the intestine,8 improve uptake of glucose into cells, and prevent adrenal hormones from stimulating the liver to produce glucose, thereby reducing blood sugar levels.9, 10

Other animal studies have shown that extracts of gymnema leaves can lower serum cholesterol and triglycerides and prevent weight gain,11, 12, 13, 14 but these effects have not been tested in humans. When placed directly on the tongue, gurmarin, another constituent of the leaves, and gymnemic acid have been shown to block the ability in humans to taste sweets.15, 16

How to Use It

Clinical trials with diabetics in India have used 400 mg per day of a water-soluble acidic fraction of the gymnema leaves. The gymnemic acid content of this extract is not clear. A recent preliminary trial in the United States reported promising results in a group of type 1 and type 2 diabetics who took 800 mg per day of an extract standardized for 25% gymnemic acids.17 Traditionally, 2 to 4 grams per day of the leaf powder is used.


Botanical names:
Gymnema sylvestre

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

Certain medicines interact with this supplement.

Types of interactions:BeneficialAdverseCheck

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • Glipizide

    Herbs such as Gymnema sylvestre will often improve blood-sugar control in diabetics.

Explanation Required

  • Glyburide
  • Insulin

    Although no interactions have been reported, gymnema may decrease the required daily dose of insulin. Therefore, people currently using insulin for the treatment of diabetes should discuss the use of this herb with their healthcare professional.

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Botanical names:
Gymnema sylvestre

Side Effects

Used at the amounts suggested, gymnema is generally safe and devoid of side effects. However, there is one case report of toxic hepatitis, possibly due to the use of gymnema.18 The safety of gymnema during pregnancy and breast-feeding has not yet been determined. People with diabetes should only use gymnema to lower blood sugar under the clinical supervision of a healthcare professional. Gymnema cannot be used in place of insulin to control blood sugar by people with either type 1 or type 2 diabetes.


1. Mhasker KS, Caius JF. A study of Indian medicinal plants. II. Gymnema sylvestre R.Br. Indian J Med Res Memoirs 1930;16:2-75.

2. Sugihara Y, Nojima H, Matsuda H, et al. Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice. J Asian Nat Prod Res 2000;2:321-7.

3. Murakami N, Murakami T, Kadoya M, et al. New hypoglycemic constituents in "gymnemic acid" from Gymnema sylvestre. Chem Pharm Bull (Tokyo) 1996;44:469-71.

4. Shanmugasundaram KR, Panneerselvam C, Sumudram P, Shanmugasundaram ERB. Insulinotropic activity of G. sylvestre, R.Br. and Indian medicinal herb used in controlling diabetes mellitus. Pharmacol Res Commun 1981;13:475-86.

5. Shanmugasundaram ER, Gopinath KL, Radha Shanmugasundaram K, Rajendran VM. Possible regeneration of the islets of Langerhans in streptozotocin diabetic rats given Gymnema sylvestre leaf extracts. J Ethnopharmacol 1990;30:265-79.

6. Prakash AO, Mather S, Mather R. Effect of feeding Gymnema sylvestre leaves on blood glucose in beryllium nitrate treated rats. J Ethnopharmacol 1986;18:143-4.

7. Persaud SJ, Al-Majed H, Raman A, Jones PM. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrinol 1999;163:207-12.

8. Shimizu K, Iino A, Nakajima J, et al. Suppression of glucose absorption by some fractions extracted from Gymnema sylvestre leaves. J Vet Med Sci1997;59:245-51.

9. [No authors listed]Gymnema sylvestre. Altern Med Rev 1999;4:46-7.

10. Gholap S, Kar A. Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Pharmazie 2003;58:413-5.

11. Bishayee A, Chatterjee M. Hypolipidemic and antiatherosclerotic effects of oral Gymnema sylvestre R.Br. leaf extract in albino rats fed on a high fat diet. Phytother Res 1994;8:118-20.

12. Shigematsu N, Asano R, Shimosaka M, Okazaki M. Effect of administration with the extract of Gymnema sylvestre R. Br leaves on lipid metabolism in rats. Biol Pharm Bull 2001;24:713-7.

13. Shigematsu N, Asano R, Shimosaka M, Okazaki M. Effect of long term-administration with Gymnema sylvestre R. BR on plasma and liver lipid in rats. Biol Pharm Bull 2001;24:643-9.

14. Nakamura Y, Tsumura Y, Tonogai Y, Shibata T. Fecal steroid excretion is increased in rats by oral administration of gymnemic acids contained in Gymnema sylvestre leaves. J Nutr 1999;129:1214-22.

15. Min BC, Sakamoto K. Influence of sweet suppressing agent on gustatory brain evoked potentials generated by taste stimuli. Appl Human Sci 1998;17:9-17.

16. Gent JF, Hettinger TP, Frank ME, Marks LE. Taste confusions following gymnemic acid rinse. Chem Senses 1999;24:393-403.

17. Joffe DJ, Freed SH. Effect of extended release gymnema sylvestre leaf extract (Beta Fast GXR) alone or in combination with oral hypoglycemics or insulin regimens for type 1 and type 2 diabetes. Diabetes In Control Newsletter 2001;76:no page number.

18. Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci 2010 Dec;340:514–7.

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