Promethazine-PhenylephrineSkip to the navigation
Common brand names:Phenergan VC
Summary of Interactions with Vitamins, Herbs, & Foods
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Potential Negative Interaction
Antihistamines, including promethazine, can cause "anticholinergic" side effects such as dryness of mouth and heart palpitations. Henbane also has anticholinergic activity and side effects. Therefore, use with promethazine could increase the risk of anticholinergic side effects, though apparently no interactions have yet been reported with promethazine and henbane. Henbane should not be taken except by prescription from a physician trained in its use, as it is extremely toxic.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Many drugs used in the treatment of high blood pressure cause relaxation or dilation of blood vessels. Laboratory studies show that emodin, a compound in Polygonum multiflorum, also relaxes blood vessels. However, animal studies reveal that phenylephrine blocks the action of emodin. Controlled studies are needed to determine whether Polygonum multiflorum helps people with high blood pressure and whether phenylephrine blocks its beneficial effects.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
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Last Review: 03-24-2015
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