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Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Reduce Side Effects
Potential Negative Interaction
Ephedra is the plant from which the drug ephedrine was originally isolated. Phenylpropanolamine and ephedrine have similar effects and side effects. Until 2004, ephedra, also called ma huang, was used in many herbal products including supplements promoted for weight loss.
While interactions between phenylpropanolamine and ephedra have not been reported, it seems likely that such interactions could occur. To prevent potential problems, people taking phenylpropanolamine-containing products should avoid using ephedra/ephedrine-containing products.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Many drugs used in the treatment of high blood pressure cause relaxation or dilation of blood vessels. Laboratory studies show that emodin, a compound in Polygonum multiflorum, also relaxes blood vessels. However, animal studies reveal that phenylephrine blocks the action of emodin. Controlled studies are needed to determine whether Polygonum multiflorum helps people with high blood pressure and whether phenylephrine blocks its beneficial effects.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
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Last Review: 03-24-2015
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