duvelisib

What is the most important information I should know about duvelisib?

Duvelisib can cause serious or fatal side effects, including serious infections, severe diarrhea, or a life-threatening skin rash.

• fever, chills, cough, breathing problems;
• severe stomach pain, diarrhea with blood or mucus; o
• painful mouth sores, or a skin rash with blistering or peeling.

What is duvelisib?

Duvelisib is used to treat adults with chronic lymphocytic leukemia or small lymphocytic leukemia. Duvelisib is also used to treat follicular lymphoma.

Duvelisib is given after at least two other cancer treatments did not work or have stopped working.

Duvelisib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking duvelisib?

Tell your doctor if you have ever had:

• an intestinal disorder such as ulcerative colitis;
• lung disease; or
• liver disease.

Keep using birth control for at least 1 month after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using duvelisib.

How should I take duvelisib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take duvelisib with or without food.

Duvelisib can cause severe diarrhea, which can be life-threatening. You may need to take medication to prevent or quickly treat diarrhea.

Your doctor will need to check your progress on a regular basis, and you will need frequent medical tests. Your cancer treatments may be delayed based on the results.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if you are more than 6 hours late for the dose. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking duvelisib?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of duvelisib?

• severe diarrhea (more than 6 bowel movements in 1 day);
• severe stomach pain, new or worsening diarrhea with blood or mucus;
• liver problems --stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or
• low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• diarrhea, nausea;
• low blood cell counts;
• bone pain, muscle pain;
• fever, cough, tiredness; or
• cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect duvelisib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect duvelisib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about duvelisib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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