avibactam and ceftazidime
What is the most important information I should know about avibactam and ceftazidime?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What is avibactam and ceftazidime?
Avibactam and ceftazidime is a combination antibiotic medicine that is used to treat complicated infections of the stomach, bladder, or kidneys in adults and children as young as 3 months old.
Avibactam and ceftazidime is used only in adults to treat pneumonia that has developed during or shortly after a hospital stay.
Avibactam and ceftazidime may also be used for purposes not listed in this medication guide.
What should I discuss with my healthcare provider before using avibactam and ceftazidime?
You should not use this medicine if you are allergic to avibactam or ceftazidime, or to a cephalosporin antibiotic such as:
- cefaclor (Ceclor);
- cefadroxil (Duricef);
- cefazolin (Ancef);
- cefdinir (Omnicef);
- cefditoren (Spectracef);
- cefprozil (Cefzil);
- ceftibuten (Cedax);
- cefuroxime (Ceftin);
- cephradine (Velosef);
- cephalexin (Keflex); and others.
Tell your doctor if you have ever had:
- a stomach or intestinal disorder such as colitis;
- kidney disease; or
- an allergy to any penicillin antibiotic (amoxicillin, ampicillin, Augmentin, dicloxacillin, oxacillin, penicillin, ticarcillin, and others).
Tell your doctor if you are pregnant or breast-feeding.
How is avibactam and ceftazidime given?
Avibactam and ceftazidime is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.
This medicine must be given slowly, and the infusion can take at least 2 hours to complete. You may need to use this medicine for up to 14 days. Follow your doctor's dosing instructions very carefully.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Avibactam and ceftazidime must be mixed with a liquid (diluent) in an IV bag. When using injections by yourself, be sure you understand how to properly mix and store the medicine.
After mixing, store the IV bag at room temperature and use it within 12 hours.
You may also store the IV bag in a refrigerator for up to 24 hours. Do not freeze. After you take the IV bag out of the refrigerator, you must use it within 12 hours.
Do not use avibactam and ceftazidime if it has changed colors or has particles in it. Call your pharmacist for new medication. The mixture should appear clear to light yellow.
Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Avibactam and ceftazidime will not treat a viral infection such as the flu or a common cold.
Call your doctor if your symptoms do not improve, or if they get worse.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using avibactam and ceftazidime.
Store unmixed avibactam and ceftazidime at room temperature away from moisture, heat, and light. Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.
Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of avibactam and ceftazidime.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using avibactam and ceftazidime?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.
What are the possible side effects of avibactam and ceftazidime?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- severe stomach pain, diarrhea that is watery or bloody;
- a seizure (convulsions);
- rigid muscles, overactive reflexes;
- confusion, hallucinations; or
- a change in your mental state.
Common side effects may include:
- nausea, vomiting;
- diarrhea; or
- bruising where the IV needle is placed.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect avibactam and ceftazidime?
Other drugs may affect avibactam and ceftazidime, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Where can I get more information?
Your doctor or pharmacist can provide more information about avibactam and ceftazidime.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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