pentosan polysulfate sodium

What is the most important information I should know about pentosan polysulfate sodium?

What is pentosan polysulfate sodium?

Pentosan polysulfate sodium is used to treat bladder pain and discomfort caused by cystitis (bladder inflammation or irritation).

Pentosan polysulfate sodium is for use in adults and children at least 16 years old.

Pentosan polysulfate sodium may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking pentosan polysulfate sodium?

Tell your doctor if you have ever had:

• a bleeding or blood clotting disorder;
• eye problems (especially a problem with your retina) in you or a family member;
• an aneurysm or stroke;
• a stomach ulcer, intestinal polyps or diverticulitis; or
• liver disease.

Tell your doctor if you are pregnant or breastfeeding.

How should I take pentosan polysulfate sodium?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your doctor will need to check your progress every 3 months to help determine how long to treat you with pentosan polysulfate sodium. You may also need blood tests and vision examinations to check for certain side effects.

If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking pentosan polysulfate sodium?

Ask a doctor or pharmacist before using any medicine that contains aspirin, ibuprofen, or similar ingredients. This includes medicine for pain, fever, swelling, or cold/flu symptoms.

What are the possible side effects of pentosan polysulfate sodium?

• nosebleeds, bleeding gums;
• blood in your urine or stools;
• rectal bleeding;
• coughing up blood;
• a light-headed feeling, like you might pass out; or
• vision problems (blurred vision, trouble reading, trouble seeing in low light).

Common side effects may include:

• bruising, blood in your stools;
• hair loss;
• nausea, diarrhea, upset stomach;
• headache;
• swelling, weight gain;
• dizziness;
• rash; or
• abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect pentosan polysulfate sodium?

Tell your doctor about all your other medicines, especially:

• a blood thinner --warfarin, Coumadin, Jantoven;
• medication used to prevent blood clots --apixaban, heparin, rivaroxaban, Eliquis, Xarelto, and others; or
• NSAIDs (nonsteroidal anti-inflammatory drugs) --aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may affect pentosan polysulfate sodium, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about pentosan polysulfate sodium.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 5.02. Revision date: 10/20/2020.