Antidepressant Withdrawal

Topic Overview

What is antidepressant withdrawal?

Antidepressant withdrawal is a problem that can happen if you stop taking your antidepressant too quickly. It can make you feel sick.

This problem is sometimes called "antidepressant discontinuation syndrome" or "SSRI discontinuation syndrome."

The symptoms may be unpleasant, but they don't usually last long. This does not mean you have substance use disorder. Moderate to severe substance use disorder is sometimes called addiction.

Most antidepressants should be stopped gradually. Doctors call it "tapering off." People who take antidepressants should never stop or taper off without a doctor's help.

What causes antidepressant withdrawal?

For most people with depression, there comes a time when they would like to stop taking their antidepressant medicine. But sometimes stopping too quickly can make you feel physically ill for a while. It happens to some people, but not others. It can even happen to people who follow a tapering plan.

Experts aren't sure why it happens. Antidepressants work by rebalancing some of your brain chemicals. So when you stop suddenly, it could be that the brain doesn't have time to get used to the change.

What are the symptoms?

Symptoms usually start within 3 days after you stop taking the medicine. The symptoms may worry you, but they're not dangerous. They usually only last a week or two.

Symptoms may include feeling like you have the flu. You may:

  • Feel very tired.
  • Have muscle aches.
  • Have a headache.
  • Have diarrhea.

You may also:

  • Have trouble sleeping.
  • Feel sick to your stomach.
  • Feel dizzy or lightheaded.
  • Have a tingling, burning, or pricking sensation on your skin.
  • Feel anxious.

How is it treated?

Tell your doctor about your symptoms. He or she may want to make sure there isn't something else wrong.

If you stopped taking your antidepressant suddenly, your doctor may have you start taking it again. But this time your doctor will give you a tapering plan. With this plan, you take smaller and smaller doses of your medicine until you're not taking it at all.

If you are already on a tapering plan and you have symptoms, your doctor may redo your plan to make it slower.

How can you prevent antidepressant withdrawal?

If you and your doctor agree that you're feeling good and are likely to stay well if you stop taking the medicine:

  • Carefully follow your tapering plan. This can help limit problems from withdrawal. It can also help lower the chance that your depression will come back.
  • Watch your symptoms. Keep a symptom diary, and share it with your doctor. Your doctor can change your tapering plan to make sure you are comfortable.
  • Tell your doctor right away if symptoms of depression return.


Other Works Consulted

  • Warner CH, et al. (2006). Antidepressant discontinuation syndrome. American Family Physician, 74(3): 449–456. Accessed December 11, 2014.


Current as of: September 23, 2020

Author: Healthwise Staff
Medical Review:
Kathleen Romito MD - Family Medicine
Lisa S. Weinstock MD - Psychiatry

Antidepressant Withdrawal