Medical School or Training
McMaster University, 1983
McMaster University Medical Center, Pediatrics, 1986
Pediatric Hematology/Oncology, University of Michigan Health System, 1990
Neuroblastoma tumor biology. Models and pathways of chemotherapy, and radiation resistance. Role of NF-kappaB signaling in the survival and death response of neuroblastoma.
Dr. Valerie Castle received her bachelor's degree from McGill University in Montreal and her medical degree from McMaster University in Hamilton, Ontario. She completed a fellowship in pediatric hematology/oncology at the University of Michigan in 1990 and joined the U-M faculty the same year. Dr. Castle currently serves as the chair for the Department of Pediatrics. Her research focuses almost exclusively on the pediatric solid tumor, neuroblastoma. She is specifically interested in mechanisms of chemotherapy and radiation resistance as well as studies on the control of neuroblastoma invasion and metastases. Dr. Castle's research interests are complemented by her clinical interest, which is also in the malignancy of neuroblastoma. She is a member of the National Cancer Coalition and has participated on the Advisory Committee for the development of the National Comprehensive Cancer Network guidelines for the clinical treatment of neuro-blastoma. Dr. Castle has received many honors and awards, including the Best Doctors in America Award and the U-M Health System Commitment to Excellence Award.