Kagan Ozer MD

Clinical Associate Professor, Orthopaedic Surgery
Orthopaedic Surgery
Clinical Interests:

Elbow, hand and microsurgery; post-traumatic reconstruction, peripheral nerve and brachial plexus reconstruction


U of M South Main Orthopaedics

Huron Valley Professional Center
2098 S Main St
Ann Arbor


Medical School or Training

  • Istanbul Universitesi, 1993


  • Taksim Hospital, Orthopedic, 1999


  • Hand Surgery, Kleinert Institute for Hand and Microsurgery, 2003

Board Certification

  • Surgery of the Hand

  • Orthopedic Surgery


Composite tissue allograft transplantation, ischemia-reperfusion injury, outcomes research.


Peer-reviewed Journals and Publications:

  1. Adanal? G, Ozer K, D’Souza S, Siemionow M. Long term effects of Inflammatory Stimuli Tumor Necrosis Factor Alpha on Microcirculatory Response for Ischemia-Reperfusion Injury. Microcirculation, 1997; 4: 173.
  2. Tetik C, Ozer K, Browne E, Siemionow M. Functional Evaluation Following Conventional Versus Epineural Sleeve Repair. Surgical Forum, American College of Surgeons 1997; 58: 542-544.
  3. Mee J, Siemionow M, Porvasnik S, Ozer K, Piza P, Zins J. Muscle Flap Response to Low Dose Radiation. Surgical Forum, American College of Surgeons 1997; 58: 745-747.
  4. Siemionow M, Ozer K, Adanali G, Gudemez E: Microcirculatory hemodynamics of transplantation trauma. FASEB 1998; 12:4: A33.
  5. Ozer K, Adanali G, Zins J, Siemionow M. In vivo microscopic assessment of cremasteric microcirculation during hindlimb allograft rejection in rats. Plast Reconstr Surg 1999; 103(7): 1949-56.
  6. Siemionow M, Mee J, Porvasnik S, Krapohl BD, Ozer K, Piza P, Zins JE. Effects of 8-Gy radiation on the microcirculation of muscle flaps in the rat. Plast Reconstr Surg. 1999; 104(5): 1372-8.
  7. Siemionow M, Ozer K, Porvasnik S, Zins J. Microcirculatory window for early detection of allograft rejection. Ann Plast Surg. 2000; 44(6): 637-43.
  8. Siemionow M, Ozer K, Siemionow W, Lister G. Robotic assistance in microsurgery. J Reconstr Microsurg. 2000; 16(8): 643-9.
  9. Ozkan T, Ozer K, Gulgonen A. Restoration of sensibility in irreparable ulnar and median nerve lesions with use of sensory nerve transfer: Long-term follow-up of 20 cases. J Hand Surg [Am]. 2001; 26(1): 44-51.
  10. Ozer K, Siemionow M. The combination of anti-ICAM-1 and anti-LFA-1 monoclonal antibody therapy prolongs allograft survival in rat hind limb transplants. J Reconst Microsurg 2001; 17(7): 511-17.
  11. Adanali G, Ozer K, Siemionow M. Acute Alterations in Muscle Flap Perfusion Following Tumor Necrosis Factor-Alpha Induced Inflammation. Ann Plast Surg 2001; 47(6): 652-9.
  12. Ozer K, Adanali G, Siemionow M. Late effects of TNF?-induced inflammation on the microcirculation of cremaster muscle flap under intravital microscopy. J Reconst Microsurg 2002; 18: 37-46.
  13. Siemionow M, Tetik C, Ozer K, Ayhan S, Siemionow K, Browne E. Epineural sleeve neurorraphy: Surgical technique and functional results. Ann Plast Surg. 2002; 48(3): 281-5.
  14. Adanali G, Ozer K, Siemionow M. Ischemic preconditioning improves microcirculatory hemodynamics of muscle flap. Plast Reconst Surg. 2002; 109(4): 1344-1351.
  15. Siemionow M, Ozer K. Advances in composite tissue allograft transplantation as related to hand and upper extremity. J Hand Surg [Am] 2002; 27(4): 565-80.
  16. Gurunluoglu R, Ozer K, Skugor B, Lubiatowski P, Carnevale K, Siemionow M. Effect of transfection time on the survival of epigastric skin flaps pretreated with adenovirus encoding the VEGF gene. Ann Plast Surg. 2002; 49(2): 161-9.
  17. Ozer K, Ortak T, Zielinski M, Izycki D, Prajapati R, Siemionow M. The Role of Chimerism in Tolerance Induction to Composite Tissue Allografts. Transplantation 2002; 74(Suppl 4): 99-100.
  18. Zielinski M, Ozer K, Zborowski M, Siemionow M. Intraosseous stem cell transplantation extends the survival of the rat hind limb allograft. Transplantation 2002; 74(Suppl 4): 195.
  19. Ozer K, Oke R, Gurunluoglu R, Izycki D, Siemionow M. Induction of tolerance to hind limb allografts under cyclosporine A and anti-lymphocyte serum treatment. Transplantation 2002; 74(Suppl 4): 314-15.
  20. Siemionow M, Ozer K, Gurunluoglu R, Zielinski M. Tolerance transfection to the naïve animals with the crude bone marrow extends limb allograft survival. Transplantation 2002; 74(Suppl 4): 616.
  21. Siemionow M, Ozer K, Unsal M, Izycki D. Crude bone marrow transplantation leads to the extension of skin allograft survival across major histocompatibility barrier. Transplantation 2002; 74(Suppl 4): 620.
  22. Tetik C, Ozer K, Ayhan S, Siemionow K, Browne E, Siemionow M. Conventional versus epineural sleeve neurorraphy technique: functional and histomorphometric analysis. Ann Plast Surg. 2002; 49: 397-403.
  23. Gudemez E, Ozer K, Cunningham B, Siemionow K, Browne E, Siemionow M. Dehydroepiandrosterone as an enhancer of the functional recovery following crush injury to the rat sciatic nerve. Microsurgery 2002; 22: 234-41.
  24. Siemionow M, Oke R, Ozer K, Prajapati R, Izycki D. Induction of donor specific tolerance in rat hind limb allografts treated with anti-lymphocyte serum and cyclosporine A. J Hand Surg [Am] 2002; 27: 1095-1103.
  25. Siemionow M, Ozer K, Unsal M, Zielinski M, Izycki D. A new method of bone marrow transplantation leads to extension of skin allograft survival across major histocompatibility barrier. Orthopedics 2002; 25(12): s1474-1475.
  26. Ozer K, Zielinski M, Unsal M, Siemionow M. Development of mouse cremaster transplantation model for intravital microscopic evaluation. Microcirculation 2002; 9(6): 487-496.
  27. Ozer K, Oke R, Gurunluoglu R, Zielinski M, Izycki D, Siemionow M. Induction of tolerance to hind limb allografts in rats under Cyclosporine A and anti-lymphocyte serum treatment: effect of duration of the treatment. Transplantation 2003; 75(1): 31-36.
  28. Ozkan T, Ozer K, Gulgonen A. Long term results of three surgical methods in the reconstruction of irreparable ulnar nerve palsy. J Hand Surg [Am] 2003; 28 (1): 35-43.
  29. Ozkan T, Ozer K, Yuksel A, Gulgonen A. Surgical reconstruction of irreversible ulnar nerve paralysis in leprosy. Leprosy Review 2003; 74(1): 53-62.
  30. Ozer K, Gurunluoglu R, Zielinski M, Izycki D, Unsal M, Siemionow M. Extension of composite tissue allograft survival across major histocompatibility barrier under short course of anti-lymphocyte serum and cyclosporine therapy. J Reconstr Microsurg 2003; 19(4): 249-255.
  31. Gurunluoglu R, Shafighi M, Ozer K, Piza-Katzer H. Practical use of digital cameras for microphotography through operating microscope. J Reconstr Microsurg. 2003; 19(5): 319-22.
  32. Ozer K, Zielinski M, Siemionow M. A new composite tissue allograft transplantation model in mouse with intravital microscopic evaluation of microcirculation. J Reconstr Microsurg. 2003; 19(5): 323-30.
  33. Scheker L, Ozer K. Electrical Stimulation in the Management of Spastic Deformity. Hand Clin. 2003;19(4): 601-6.
  34. Ozkan T, Aydin T, Ozer K, Ozturk K, Durmaz H, Ozkan S. A surgical technique for pediatric forearm pronation: brachioradialis rerouting with interosseous membrane release. J Hand Surg [Am]. 2004; 29(1):22-7.
  35. Siemionow M, Ulusal BG, Ozmen S, Ulusal AE, Ozer K. Composite vascularized skin/bone graft model: A viable source for vascularized bone marrow transplantation. Microsurgery 2004; 24(3): 200-6.
  36. Ozer K, Izycki D, Zielinski M, Siemionow M. Development of donor-specific chimerism and tolerance in composite tissue allografts under -T-cell receptor monoclonal antibody and cyclosporine a treatment protocols. Microsurgery 2004; 24(3): 248-54.
  37. Scheker L, Ozer K. Ligamentous stabilization of the distal radioulnar joint. Tech in Hand and Upper Extremity Surg 2004; 8(4): 239-46.
  38. Scheker L, Ozer K. A Simple Method of Physical Examination for the Diagnosis of Distal Radioulnar Joint Incongruency. Eur J Plast Surg. 2004; 27(1): 42-3.
  39. Siemionow M, Ozer K, Izycki D, Unsal M, Klimczak A. A new method of bone marrow transplantation leads to extension of skin allograft survival. Transplant Proc. 2005; 37(5):2309-14.
  40. Ozer K, Scheker L. Distal radioulnar joint: Problems and solutions. Orthopedics 2006; 29 (1): 38-49.
  41. Peterson SL, Ozer K. Flexor tendon rupture 55 years following a wrist laceration. J Plast Recons Aesth Surg 2006; 59: 529-31.
  42. Ozer K, Smith W. A simple technique for applying vacuum assisted closure therapy over the circular type external fixation device. Ann Plast Surg 2006; 56: 693-4.
  43. Siemionow M, Izycki D, Ozer K, Ozmen S, Klimczak A. Role of thymus in operational tolerance induction in limb allograft transplant model. Transplantation. 2006; 81(11): 1568-76.
  44. Ozer K, Chesher SP, Scheker LR. Neuromuscular electric stimulation and dynamic bracing for the management of upper extremity spasticity in children with cerebral palsy. Dev Med Child Neurol. 2006; 48(7): 559-63.
  45. Ozer K. A new surgical technique for the ligament reconstruction of the trapeziometacarpal joint. Tech Hand Upper Extr Surg 2006; 10(3): 181-6.
  46. Ozer K, Peterson S. Phalangeal osteochondroma on a 2 year-old child. Orthopedics 2006; 29 (10): 943-4.
  47. Chandrasekharan UM, Siemionow M, Unsal M, Yang L, Poptic E, Bohn J, Ozer K, Zhou Z, Howe PH, Penn M, DiCorleto PE. Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo. Blood. 2007; 109 (5):1938-44.
  48. Gulgonen A, Ozer K. Correction of postburn contractures of second through fourth web space. J Hand Surg 2007; 32(A): 556-64.
  49. Morgan S, Newman J, Ozer K, Smith W, Gurunluoglu R. Salvage of a below-the-knee amputation level following a type-IIIB open tibial fracture. J Bone Joint Surg (Am) 2007; 89: 2769-78.
  50. Lubiatowski P, Unsal FM, Nair D, Ozer K, Siemionow M. The epineural sleeve technique for nerve graft reconstruction enhances nerve recovery. Microsurgery. 2008; 28: 160-7.
  51. Peterson SL, Lee LA, Ozer K, Fitzpatrick JE. Tattoo pigment interpreted as lymph node metastasis in a case of subungual melanoma. Hand (N Y). 2008; 3(3): 282-5.
  52. Ozer K, Gillani S, Williams A, Peterson S, Morgan S. Comparison of intramedullary nailing versus plate-screw fixation of metacarpal fractures. J Hand Surg (Am)(2008; 33A: 1724–31).
  53. Williams AE, Newman JT, Ozer K, Juarros A, Morgan SJ, Smith W. The impact of posttraumatic stress disorder and depression on functional status in patients with hand injuries. J Hand Surg 2009; 34A: 515-22.
  54. Ozer K, Smith W. Limb salvage in the treatment of total muscle necrosis of the leg due to compartment syndrome. J Bone Joint Surg (Am) 2009; 91: 2708-12.
  55. Ozer K, Kramer W, Gillani S, Williams A, Smith W. Replantation Versus Revision of Amputated Fingers in Patients Air-Transported to a Level 1 Trauma Center. J Hand Surg 2010; 35A: 936–940.
  56. Ozer K, Gillani S, Williams A, Hak D. Psychiatric Risk Factors in Pediatric Hand Fractures. J Pediatr Orthop 2010; 30: 324–7.
  57. Ozer K, Hak D. Clinically Successful Wrist Fusion Using Cancellous Bone Allograft. Current Orthopaedic Practice 2010; 21: 582-5.
  58. Toker S, Ozer K. Avascular necrosis of the capitate. Orthopedics 2010; 33(11): 850.
  59. Cao J, Ozer K. Failure of volar locking plate fixation of an extraarticular distal radius fracture: A case report. Patient Saf Surg. 2010; 4(1): 19.
  60. Ozer K, Toker S, Morgan S. The use of a combined rib-latissimus dorsi flap for elbow arthrodesis and soft-tissue coverage. J Shoulder Elbow Surg 2011; 20: e9-13.
  61. Muratore T, Ozer K. Persistent median artery in a pediatric trauma patient: Case report. J Hand Surg 2011; 36A: 658–660.
  62. Ozer K, Toker S. Dorsal tangential view of the wrist to detect screw penetration to the dorsal cortex of the distal radius after volar fixed-angle plating. Hand 2011; 6: 190-193.
  63. Wolf JM, Ozer K, Scott F, Gordon MJ, Williams AE. Comparison of autologous blood, corticosteroid and saline injection in the treatment of lateral epicondilitis: A prospective, randomized, controlled multicenter study. J Hand Surg 2011; 36: 1269-72.
  64. Ozer K, Kilic A, Sabel A, Ipaktchi K. The role of bone allografts in the treatment of angular malunions of the distal radius. J Hand Surg 2011; 36A: 1804–1809.
  65. Gulgonen A, Ozer K. Long-term results of major upper extremity replantations. J Hand Surg Eur 2012; 37: 225-32.