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Extracorporeal support can significantly increase number of organs available for transplant

U-M research shows using heart-lung support machine for donations after circulatory death boosted pool of available organs by 20 percent

Ann Arbor, Mich. — Using heart-lung support technology, the University of Michigan’s Transplant Center was able to increase the number of kidneys, livers and pancreases available for transplant by about 20 percent.

The results were published in the journal Transplantation and detail the impact of more than 10 years of using Extracorporeal Membrane Oxygenation, or ECMO, to improve the quality and viability of organs donated after circulatory determination of death.

“Organ transplant is limited by the number of donated organs available, so the use of organs that are donated after circulatory death is one way to increase the number of life-saving organs available for patients waiting for that gift of life,” says Alvaro Rojas-Pena, M.D., the lead author on the study and a research investigator for transplant surgery at the University of Michigan Health System.

As of Aug. 6, 2014, 123,191 people nationwide were waiting for a solid organ transplant in the United States. The Institute of Medicine has named donation after circulatory determination of death as the number one research priority to improve organ donation.

However, donation after circulatory death accounts for just six to eight percent of organ transplants in the United States, almost exclusively limited to renal grafts. The most common process used to procure these organs still results in injury or failure of the organ.

A donation after circulatory determination of death comes from a donor who has suffered irreversible brain injury, but does not meet formal brain death criteria. In these cases, the family has decided to withdraw care.

At the University of Michigan, once the family makes the decision about organ donation, the patient can be connected to ECMO to improve the viability of any organs for donation.

ECMO was developed in the 1970s by U-M surgeon Robert Bartlett, now a professor emeritus. The technology does the work of a patient’s failing heart and lungs for a period of weeks, sometimes months.

In the transplant cases studied form Oct 1, 2000 to July 31, 2013, ECMO was used in 37 donations after circulatory death. The number of organs procured per donor was 2.59 and the number of organs transplanted per donor was 1.68.

The study also showed there was little to no difference in survival rates from organs donated after circulatory death procured after ECMO compared with those procured using other methods.

“We had this program here of ECMO that was highly successful so we began using it to expand the number of organs available for transplant,” says Jeffrey Punch, M.D., a University of Michigan transplant surgeon, professor of surgery and senior author of the study.

“We believe it has made the organs work better as well. When you talk to families of organ donors, the one thing they really want to know is whether worked. If you can tell them this makes the organs work better, this really offers quite a bit of comfort to them.”

“Any increase in the organs available for transplant is meaningful for those waiting for a life-saving donation,” Punch says. “We hope these results will encourage other centers to consider this process in organ procurement.”

Additional authors: Of the University of Michigan: Lauren E. Sall, B.S.; Mark T. Gravel, R.N.; Elaine G. Cooley, R.N. and Robert H. Bartlett, M.D. Of the University of Virginia: Shawn J. Pelletier.

Journal citation: 10.1097/TP.0000000000000070

Disclosures: None

About the University of Michigan Transplant Center: U-M has one of the oldest and largest transplantation programs in the country and U-M surgeons perform transplants of hearts, lungs, pancreases, livers, kidneys, and corneas. About 400 to 450 transplants are done at U-M annually, mostly kidney transplants followed by liver, heart, lung and pancreas. In 2014, the center performed its 10,000th solid organ transplant.


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