Media Contact: Laura Williams, Life Sciences Institute (734) 615-4862

Old drug may point the way to new treatments for diabetes and obesity

ANN ARBOR, Mich.

Researchers at the University of Michigan's Life Sciences Institute have found that amlexanox, an off-patent drug currently prescribed for the treatment of asthma and other uses, also reverses obesity, diabetes and fatty liver in mice.

The findings from the lab of Alan Saltiel, the Mary Sue Coleman director of the Life Sciences Institute, are scheduled to be published online Feb. 10 in the journal Nature Medicine.

"One of the reasons that diets are so ineffective in producing weight loss for some people is that their bodies adjust to the reduced calories by also reducing their metabolism, so that they are 'defending' their body weight," Saltiel said. "Amlexanox seems to tweak the metabolic response to excessive calorie storage in mice."

To read the rest of this story, please follow this link to the full text on the U-M News Service website:

http://www.ns.umich.edu/new/releases/21179-old-drug-may-point-the-way-to-new-treatments-for-diabetes-and-obesity

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