Antidepressant medicines, which are usually used to treat
depression, can be effective in preventing chronic
tension headaches. Antidepressants have some
pain-relieving properties and may reduce how often headaches occur and how long
they last. Antidepressants are also used to improve sleep problems.
Tricyclic antidepressants, such as amitriptyline, are the
antidepressants used most often to reduce the frequency or duration of tension
Medicines to prevent tension headaches have not been well studied.
The best evidence is for amitriptyline. It has been
proven to reduce how often tension headaches occur and how bad they get.footnote 1 If you do not respond well to
amitriptyline, you may try other tricyclic antidepressants, although they may
not work as well to relieve your headache.
effects of tricyclic antidepressants include:
Drowsiness or sleepiness.
Inability to urinate.
Low blood pressure when you stand up quickly.
Other antidepressants used to prevent tension
headaches include mirtazapine (Remeron) and venlafaxine (Effexor).
The U.S. Food and Drug Administration (FDA) has issued
an advisory on antidepressant medicines and the risk of suicide.
Talk to your doctor about these possible
side effects and the warning signs of suicide.
Jackson JL, et al. (2010). Tricyclic antidepressants and headaches: Systematic review and meta-analysis. BMJ. Published online October 20, 2010 (doi:10.1136/bmj.c5222).