Parts Used & Where Grown
Passion flower is a climbing vine renowned for its beautiful white flowers with purple, blue, or pink calyx crown blooms. The plant is native to North, Central, and South America. While primarily tropical, some of its 400 species can grow in colder climates. The mystery of such a beautiful blossom emerging from an unassuming bud has been compared to the Passion of Christ. This inspired the plant’s name, which dates back to the 17th century. The leaves, stems, and flowers are used for medicinal purposes.
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This supplement has been used in connection with the following health conditions:
|100 to 200 mg valerian and 45 to 90 mg passion flower three times a day||A combination of passion flower and valerian has been shown to reduce symptoms in people suffering from anxiety.|
100 to 200 mg valerian and 45 to 90 mg passion flower three times a day
Several plants, known as “nervines” (nerve tonics), are used in traditional herbal medicine for people with anxiety, with few reports of toxicity. Most nervines have not been rigorously investigated by scientific means to confirm their efficacy. However, one study found that a combination of the nervines valerian and passion flower reduced symptoms in people suffering from anxiety.3 In a double-blind study, 45 drops per day of an extract of passion flower taken for four weeks was as effective as 30 mg per day of oxazepam (Serax), a medication used for anxiety.4
|Refer to label instructions||Passion flower is commonly recommended by doctors as a mild sedative for those suffering from insomnia or nervous exhaustion.|
Combining valerian root with other mildly sedating herbs is common both in Europe and the United States. Chamomile, hops, passion flower, lemon balm, American scullcap, and catnip are commonly recommended by doctors.5 These herbs can also be used alone as mild sedatives for those suffering from insomnia or nervous exhaustion. Chamomile is a particularly good choice for younger children whose insomnia may be related to gastrointestinal upset. Hops and lemon balm are approved by the German government for relieving sleep disturbances.6 In a double-blind trial, the combination of valerian root and hops was significantly more effective than valerian root alone for treating insomnia.7
|Refer to label instructions||Passion flower has been historically used to relieve pain.|
Traditional Use (May Not Be Supported by Scientific Studies)
The historical use of passion flower is not dissimilar to its current use as a mild sedative. Medicinal use of the herb did not begin until the late 19th century in the United States. Passion flower was used to treat nervous restlessness and gastrointestinal spasms. In short, the effects of passion flower were believed to be primarily on the nervous system, particularly for anxiety due to mental worry and overwork.1
The effectiveness of passion flower as a treatment for anxiety has been confirmed in a double-blind study. In that study, 45 drops per day of an extract of passion flower taken for four weeks was as effective as 30 mg per day of oxazepam (Serax®), a medication used for anxiety.2
How It Works
How It Works
For many years, plant researchers believed that a group of harman alkaloids were the active constituents in passion flower. Recent studies, however, have pointed to the flavonoids in passion flower as the primary constituents responsible for its relaxing and anti-anxiety effects.8 European herbal pharmacopoeias typically recommend passion flower products containing no less than 0.8% total flavonoids. The European literature involving passion flower recommends it primarily for the treatment of mild to moderate anxiety. In this context, it is often combined with valerian, lemon balm, and other herbs with sedative properties.
How to Use It
The recommended intake of the dried herb is 4–8 grams per day.9 To make a tea, 0.5 to 2.5 grams of the herb can be steeped with boiling water for ten to fifteen minutes and drunk two to three times per day. Alternatively, 5–10 ml of passion flower tincture can be taken three to four times per day.
Interactions with Supplements, Foods, & Other Compounds
Some practitioners suggest not using passion flower with MAO-inhibiting antidepressant drugs because of concerns that they may interact with the harman alkaloids in passion flower.10 However, this interaction is theoretical and has not been reported in the medical literature.
Interactions with Medicines
Used in the recommended amounts, passion flower is generally safe and has not been found to adversely interact with other sedative drugs. A single case has been reported of a 34-year-old female who developed severe nausea, vomiting, drowsiness, and heart symptoms following self-administration of passion flower. It is not known for certain if passion flower caused her symptoms.11 Passion flower has not been proven to be safe during pregnancy and breast-feeding.
1. Foster S. Herbs for Your Health. Loveland, CO: Interweave Press, 1996, 68–9.
2. Akhondzadeh S, Naghavi HR, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363–7.
3. Brown D. Valerian root: Non-addictive alternative for insomnia and anxiety. Quart Rev Nat Med 1994;Fall:221–4 [review].
4. Akhondzadeh S, Naghavi HR, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363–7.
5. Brown DJ. Herbal Prescriptions for Better Health. Rocklin, CA: Prima Publishing, 1996, 279.
6. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 147, 160–1.
7. Koetter U, Schrader E, Käufeler R, Brattström A. A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. Phytother Res 2007;21:847-51.
8. Meier B. Passiflora incarnata L.—Passion flower: Portrait of a medicinal plant. Zeitschrift Phytother 1995;16:115–26.
9. Wichtl M. Herbal Drugs and Phytopharmaceuticals. Boca Raton, FL: CRC Press, 1994, 363–5.
10. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 206–7.
11. Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63–6.
Last Review: 08-17-2011
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.
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