clopidogrel

NOTICE: This health information was not created by the University of Michigan Health System (UMHS) and may not necessarily reflect specific UMHS practices. For medical advice relating to your personal condition, please consult your doctor. Complete disclaimer

clopidogrel

Pronunciation: kloe PID oh grel
Brand: Plavix

Plavix 75 mg

round, pink, imprinted with 75, 1171

Image of Plavix 75 mg
slide 1 of 1
    

What is the most important information I should know about clopidogrel?

Clopidogrel keeps your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions. Because of this drug action, clopidogrel can make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

emt You may also have bleeding on the inside of your body, such as in your stomach or intestines. Call your doctor at once if you have black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds. These could be signs of bleeding in your digestive tract.
noalcohol Avoid drinking alcohol. It may increase your risk of bleeding in your stomach or intestines.
emt If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using clopidogrel. You may need to stop using the medicine for at least 5 days before having surgery, to prevent excessive bleeding. Follow your doctor's instructions and start taking clopidogrel again as soon as possible.
donot While you are taking clopidogrel, do not take aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) without your doctor's advice. NSAIDs include ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), meloxicam (Mobic), and others.

Tell your doctor about all other medicines you use to prevent blood clots.

What is clopidogrel?

Clopidogrel keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.

Clopidogrel is used to prevent blood clots after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels.

Clopidogrel may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking clopidogrel?

donot Do not use this medication if you are allergic to clopidogrel, or if you have any active bleeding such as a stomach ulcer or bleeding in the brain (such as from a head injury).

If you have any of these other conditions, you may need a dose adjustment or special tests:

  • a bleeding or blood clotting disorder, such as TTP (thrombocytopenic purpura) or hemophilia;
  • a history of stroke, including TIA ("mini-stroke");
  • a stomach ulcer or ulcerative colitis; or
  • kidney disease.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

nobrfeed It is not known whether clopidogrel passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking clopidogrel.

How should I take clopidogrel?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

water Take this medication with a full glass of water.

Clopidogrel can be taken with or without food.

Because clopidogrel keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

emt If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using clopidogrel. You may need to stop using the medicine for at least 5 days before having surgery, to prevent excessive bleeding. Follow your doctor's instructions and start taking clopidogrel again as soon as possible.
donot Do not stop using clopidogrel without first talking to your doctor. Use clopidogrel regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

To be sure this medicine is not causing harmful effects, your blood will need to be tested often. Visit your doctor regularly.

rt Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

emt Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include vomiting, feeling exhausted or short of breath, and blood in your stools or vomit.

What should I avoid while taking clopidogrel?

donot While you are taking clopidogrel, do not take aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) without your doctor's advice. NSAIDs include ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), meloxicam (Mobic), and others.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

noalcohol Avoid drinking alcohol. It may increase your risk of bleeding in your stomach or intestines.

What are the possible side effects of clopidogrel?

emt Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
donot Stop using clopidogrel and call your doctor at once if you have any of these serious side effects:
  • nosebleed or other bleeding that will not stop;
  • bloody or tarry stools, blood in your urine;
  • coughing up blood or vomit that looks like coffee grounds;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance;
  • pale skin, weakness, fever, or jaundice (yellowing of the skin or eyes); or
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.

Less serious side effects may include itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect clopidogrel?

Tell your doctor about all other medicines you use to prevent blood clots, including:

  • abciximab (ReoPro);
  • dalteparin (Fragmin);
  • drotrecogin alfa (Xigris);
  • enoxaparin (Lovenox);
  • eptifibatide (Integrilin);
  • fondaparinux (Arixtra);
  • heparin;
  • ticlopidine (Ticlid);
  • tinzaparin (Innohep);
  • tirofiban (Aggrastat);
  • urokinase (Abbokinase); and
  • warfarin (Coumadin).

Tell your doctor about all other medicines you use, especially:

  • armodafanil (NuVigil) or modafanil (Provigil);
  • fluoxetine (Prozac) or fluvoxamine (Luvox);
  • gemfibrozil (Lopid);
  • isoniazid (Rifamate, Rifater);
  • a cancer medication such as dasatinib (Sprycel), letrozole (Femara), ibritumomab (Zevalin), or tositumomab (Bexxar);
  • certain stomach acid reducers, such as cimetidine (Tagamet), esomeprazole (Nexium), dexlansoprazole (Kapidex), lansoprazole (Prevacid), omeprazole (Prilosec, Prilosec OTC, Zegerid), pantoprazole (Protonix), or rabeprazole (AcipHex);
  • an antifungal medication such as fluconazole (Diflucan), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend);
  • HIV medications such as delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), or tipranavir (Aptivus); or
  • seizure medication such as felbamate (Felbatol) or oxcarbamazepine (Trileptal).

This list is not complete and other drugs may interact with clopidogrel. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about clopidogrel.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2011 Cerner Multum, Inc. Version: 10.01. Revision date: 2/1/2011.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.